Protsenko Yuri L, Klinova Svetlana V, Gerzen Oksana P, Privalova Larisa I, Minigalieva Ilzira A, Balakin Alexander A, Lookin Oleg N, Lisin Ruslan V, Butova Ksenya A, Nabiev Salavat R, Katsnelson Leonid B, Nikitina Larisa V, Katsnelson Boris A
Institute of Immunology and Physiology of the Ural Branch of the Russian Academy of Sciences, Yekaterinburg, Russia.
Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, Yekaterinburg, Russia.
Toxicol Rep. 2020 Mar 2;7:433-442. doi: 10.1016/j.toxrep.2020.03.001. eCollection 2020.
Subchronic intoxications induced in male rats by repeated intraperitoneal injections of lead acetate and cadmium chloride, administered either alone or in combination, are shown to affect the biochemical, cytological and morphometric parameters of blood, liver, heart and kidneys. The single twitch parameters of myocardial trabecular and papillary muscle preparations were measured in the isometric regime to identify changes in the heterometric (length-force) and chronoinotropic (frequency-force) contractility regulation systems. Differences in the responses of these systems in trabecules and papillary muscles to the above intoxications are shown. A number of myocardium mechanical characteristics changing in rats under the effect of a combined lead-cadmium intoxication and increased proportion of α-myosin heavy chains were observed to normalize fully or partially if such intoxication was induced against background administration of a proposed bioprotective complex. Based on the experimental results and literature data, some assumptions are suggested concerning the mechanisms of the cardiotoxic effects produced by lead and cadmium.
通过对雄性大鼠反复腹腔注射醋酸铅和氯化镉单独或联合给药诱导的亚慢性中毒，显示会影响血液、肝脏、心脏和肾脏的生化、细胞学和形态学参数。在等长状态下测量心肌小梁和乳头肌制剂的单收缩参数，以确定异长（长度-张力）和变时性（频率-张力）收缩调节系统的变化。显示了这些系统在小梁和乳头肌中对上述中毒的反应差异。观察到在联合铅镉中毒作用下大鼠心肌的一些力学特性发生变化，并且α-肌球蛋白重链比例增加，如果在给予一种提议的生物保护复合物的背景下诱导这种中毒，这些变化会完全或部分恢复正常。基于实验结果和文献数据，提出了一些关于铅和镉产生心脏毒性作用机制的假设。
