The Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, Yekaterinburg, Russia.
Institute of Industrial Ecology, The Urals Branch of the Russian Academy of Sciences, Ekaterinburg, Russia.
Nanotoxicology. 2021 Mar;15(2):205-222. doi: 10.1080/17435390.2020.1845410. Epub 2020 Nov 13.
Moderate subchronic intoxication was induced in rats by repeated intraperitoneal injections of PbO (49.6 ± 16.0 nm) and/or CdO (57.0 ± 13.0 nm) nanoparticles (NP) three times a week during 6 weeks. In particular, there was a reduction in arterial blood pressure and in blood concentrations of a number of factors controlling vasoconstriction and vasodilation, particularly of endothelin 1 (ET-1). This toxic effect was attenuated with a bioprotective complex administered in the background. The study confirmed as well that the combined binary action typology varies depending on which effect it is estimated by.
通过每周三次腹膜内注射 PbO（49.6±16.0nm）和/或 CdO（57.0±13.0nm）纳米颗粒（NP），在大鼠中诱导中度亚慢性中毒，持续 6 周。特别是，动脉血压降低，控制血管收缩和舒张的多种因子的血液浓度降低，尤其是内皮素 1（ET-1）。这种毒性作用可以通过给予生物保护复合物来减轻。研究还证实，二元联合作用类型学取决于所估计的影响而有所不同。
