Minchenko A G
Vopr Med Khim. 1988 Sep-Oct;34(5):17-22.
Biosynthesis of different groups of mitochondrial proteins was studied in liver cells of control and thyroidectomized rats after hydrocortisone administration. The hormone augmented protein biosynthesis in liver mitochondria within 15 min but the effect was less distinct in thyroidectomized rats. After hydrocortisone administration into intact rats the rate of liver mitochondrial proteins biosynthesis, coded by mitochondrial genes, was considerably higher as compared with those effects of nuclear genes, while biosynthesis of mitochondrial proteins was similarly increased in thyroidectomized rats. Hydrocortisone stimulated protein biosynthesis in matrix, inner and outer mitochondrial membranes of intact and thyroidectomized rats, whereas the biosynthesis was altered less distinctly in outer membranes. These data suggest that the effect of hydrocortisone on biosynthesis of proteins in mitochondria depended on content of thyroid hormones.
在给对照大鼠和甲状腺切除大鼠注射氢化可的松后，研究了不同组线粒体蛋白的生物合成情况。该激素在15分钟内增强了肝线粒体中的蛋白生物合成，但在甲状腺切除大鼠中效果不太明显。给完整大鼠注射氢化可的松后，由线粒体基因编码的肝线粒体蛋白生物合成速率与核基因的作用相比显著更高，而在甲状腺切除大鼠中线粒体蛋白的生物合成也有类似增加。氢化可的松刺激了完整大鼠和甲状腺切除大鼠线粒体基质、内膜和外膜中的蛋白生物合成，而在外膜中生物合成的变化不太明显。这些数据表明，氢化可的松对线粒体中蛋白生物合成的作用取决于甲状腺激素的含量。
