[不同机体甲状腺激素水平下氢化可的松对大鼠肝细胞线粒体和细胞质RNA生物合成作用的特征]
[Characteristics of hydrocortisone action on the biosynthesis of mitochondrial and cytoplasmic RNA in rat liver cells at different thyroid hormone levels in the body].
作者信息
Minchenko A G
出版信息
Farmakol Toksikol. 1987 Mar-Apr;50(2):71-3.
PMID:2438155
Abstract
Hydrocortisone effect on RNA synthesis was shown to depend on thyroid hormone levels: the inducing action of hydrocortisone on RNA synthesis in liver mitochondria was revealed only in intact and triiodothyronine-treated thyroidectomized rats. In hypothyrosis hydrocortisone failed to produce a significant change in intensity of mitochondrial and cytoplasmic RNA synthesis.
摘要
氢化可的松对RNA合成的影响取决于甲状腺激素水平：氢化可的松对肝线粒体RNA合成的诱导作用仅在完整的和经三碘甲状腺原氨酸处理的甲状腺切除大鼠中显现。在甲状腺功能减退时，氢化可的松未能使线粒体和细胞质RNA合成强度发生显著变化。
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