Galkin B N, Ershova O N, Golovenko N Ia, Zhilina Z I, Oleshko T I
Vopr Med Khim. 1988 Sep-Oct;34(5):91-3.
Tetraphenyl porphyrin (TPP) and its complexes with Fe3+, Co2+, Cu2+, Zn2+ and Ni2+ inhibited cytochrome P-450-dependent enzymes in rat liver microsomes. Content of cytochrome P-450 was decreased by 27% or 49% depending on the substance administered (TPP or its metal complexes, respectively). N-demethylase was inactivated by about 30%; the rate of aniline p-hydroxylation was decreased by 30-45% depending on the type of the metal complex. But these substances did not affect practically the benz(alpha)pyrene hydroxylase activity. The inhibitory effect of TPP of its metal complexes appears to occur due to activation of lipid peroxidation and of hemoxygenase, which is responsible for biodegradation of hem in cytochrome P-450.
四苯基卟啉（TPP）及其与Fe3+、Co2+、Cu2+、Zn2+和Ni2+形成的配合物可抑制大鼠肝微粒体中细胞色素P - 450依赖的酶。细胞色素P - 450的含量根据所给予的物质（分别为TPP或其金属配合物）降低了27%或49%。N - 脱甲基酶失活约30%；苯胺对羟基化速率根据金属配合物的类型降低了30 - 45%。但这些物质实际上并不影响苯并（α）芘羟化酶的活性。TPP及其金属配合物的抑制作用似乎是由于脂质过氧化和血红素加氧酶的激活而产生的，血红素加氧酶负责细胞色素P - 450中血红素的生物降解。
