Ecker Nóra, Pápai Zsuzsanna
Onkológiai Osztály, Magyar Honvédség Egészségügyi Központ, Budapest, Hungary.
Magy Onkol. 2020 Mar 17;64(1):56-61. Epub 2020 Feb 11.
Based on our current knowledge, 5-10% of all malignancies are part of hereditary cancer syndromes. Although the increasing diagnostic role of molecular genetic testing makes us able to recognize more hereditary cancer patients, the careful exploration of family and clinical history by physicians is still the most important step for the diagnosis. In our review we deal with mesenchymal tumours associated with hereditary syndromes. Sarcomas comprise only 1% of all malignancies, but they often associate with familiar diseases so they can serve as an indicator of these syndromes. The diagnosis of hereditary cancer predisposition syndromes is essential to ensure appropriate therapy and follow-up for our patients.
根据我们目前的认知，所有恶性肿瘤中有5% - 10%属于遗传性癌症综合征。尽管分子基因检测在诊断中的作用日益增强，使我们能够识别出更多遗传性癌症患者，但医生对家族史和临床病史的仔细探究仍是诊断的最重要步骤。在我们的综述中，我们探讨了与遗传性综合征相关的间叶组织肿瘤。肉瘤仅占所有恶性肿瘤的1%，但它们常与家族性疾病相关，因此可作为这些综合征的一个指标。遗传性癌症易感性综合征的诊断对于确保为我们的患者提供适当的治疗和随访至关重要。
