Faculty of Health Sciences, Marien Ngouabi University, Brazzaville, Congo.
Laboratory of Parasitology-Mycology, Edith Lucie Bongo Ondimba General Hospital, Oyo, Congo.
Mycoses. 2020 Jun;63(6):543-552. doi: 10.1111/myc.13075. Epub 2020 Apr 16.
The Republic of Congo (RoC) is characterised by a high prevalence of tuberculosis and HIV/AIDS, which largely drive the epidemiology of serious fungal infections.
We aimed to estimate the current burden of serious fungal infections in RoC.
Using local, regional or global data and estimates of population and at-risk population groups, deterministic modelling was employed to estimate national incidence or prevalence of the most serious fungal infections.
Our study revealed that about 5.4% of the Congolese population (283 450) suffer from serious fungal infections yearly. The incidence of cryptococcal meningitis, Pneumocystis jirovecii pneumonia and disseminated histoplasmosis in AIDS patients was estimated at 560, 830 and 120 cases per year. Oral and oesophageal candidiasis collectively affects 12 320 HIV-infected patients. Chronic pulmonary aspergillosis, 67% post-tuberculosis, probably has a prevalence of 3420. Fungal asthma (allergic bronchopulmonary aspergillosis and severe asthma with fungal sensitisation) probably has a prevalence of 3640 and 4800, although some overlap due to disease definition is likely. The estimated prevalence of recurrent vulvovaginal candidiasis and tinea capitis is 85 440 and 178 400 respectively. Mostly related to agricultural activity, fungal keratitis affects an estimated 700 Congolese yearly.
These data underline the urgent need for an intensified awareness towards Congolese physicians to fungal infections and for increased efforts to improve diagnosis and management of fungal infections in the RoC.
刚果共和国（刚果（布））的特点是结核病和艾滋病毒/艾滋病的发病率很高，这在很大程度上推动了严重真菌感染的流行病学发展。
我们旨在估计刚果（布）严重真菌感染的当前负担。
使用当地、区域或全球数据以及人口和高危人群估计数，采用确定性模型来估计国家最严重真菌感染的发病率或患病率。
我们的研究表明，每年约有 5.4%的刚果人（283450 人）患有严重真菌感染。艾滋病患者中隐球菌性脑膜炎、卡氏肺孢子虫肺炎和播散性组织胞浆菌病的发病率估计为每年 560、830 和 120 例。口腔和食管念珠菌病共同影响 12320 名 HIV 感染者。慢性肺曲霉病（67%与肺结核后相关）可能的患病率为 3420 例。真菌性哮喘（变应性支气管肺曲霉病和真菌致敏性严重哮喘）可能的患病率分别为 3640 和 4800 例，尽管由于疾病定义的重叠，可能存在一些重叠。复发性外阴阴道念珠菌病和头癣的估计患病率分别为 85440 和 178400 例。真菌性角膜炎主要与农业活动有关，估计每年影响约 700 名刚果人。
这些数据强调刚果医生迫切需要提高对真菌感染的认识，并加大努力改善刚果（布）真菌感染的诊断和管理。
