Faculty of Medicine, Department of Otorhinolaryngology, 221266Bezmialem Vakif University, Istanbul, Turkey.
Faculty of Medicine, Department of Ophthalmology, 221266Bezmialem Vakif University, Istanbul, Turkey.
Ear Nose Throat J. 2021 Sep;100(5_suppl):808S-812S. doi: 10.1177/0145561320908480. Epub 2020 Mar 17.
Allergic rhinitis is a type 1 hypersensitivity reaction of immunoglobulin E in the rhino-ocular mucosa. This study was planned to demonstrate in patients with allergic rhinitis to evaluate changes in tear, nasal secretions, and blood osmolarity compared to healthy individuals.
Forty allergic rhinitis patients, 25 patients with acute upper respiratory tract infections, and 26 healthy participants were included in the study. Positive patients with allergic symptoms and skin prick test results were included in the allergic rhinitis group. Tear, nasal secretion, and blood osmolarity values were examined for the 3 groups.
In patients with allergic rhinitis, tear and nasal secretion osmolarity values were significantly higher in patients with acute upper respiratory tract infections and those of the healthy participants ( = .001, = .038). In blood osmolarity measurements, there was no statistical difference between the groups ( = .489). In patients with allergic rhinitis, Schirmer test results were significantly shorter than patients who had acute upper respiratory tract infection and those of the healthy participants ( = .001, = .001). Patients with allergic rhinitis and acute upper respiratory tract infections had significantly shorter Schirmer test results than in healthy participants ( = .001, = .001).
Tear osmolarity was increased in allergic rhinitis patients, and this was thought to lead to dry eye findings. In the presence of allergic rhinitis, nasal secretions were found more hyperosmolar than tears. Nasal secretion osmolarity was higher in allergic rhinitis patients than in patients with acute upper respiratory tract infections and control group.
变应性鼻炎是免疫球蛋白 E 在鼻-眼黏膜中的 1 型超敏反应。本研究旨在评估变应性鼻炎患者的泪液、鼻分泌物和血液渗透压的变化，并与健康个体进行比较。
将 40 例变应性鼻炎患者、25 例急性上呼吸道感染患者和 26 例健康参与者纳入本研究。纳入具有变应性症状和皮肤点刺试验结果阳性的患者进入变应性鼻炎组。对 3 组患者的泪液、鼻分泌物和血液渗透压值进行检查。
在变应性鼻炎患者中，急性上呼吸道感染患者和健康参与者的泪液和鼻分泌物渗透压值明显高于变应性鼻炎患者（=0.001，=0.038）。在血液渗透压测量中，各组之间无统计学差异（=0.489）。在变应性鼻炎患者中，Schirmer 测试结果明显短于急性上呼吸道感染患者和健康参与者（=0.001，=0.001）。变应性鼻炎和急性上呼吸道感染患者的 Schirmer 测试结果明显短于健康参与者（=0.001，=0.001）。
变应性鼻炎患者的泪液渗透压升高，这被认为会导致干眼症的发现。在变应性鼻炎存在的情况下，鼻分泌物比泪液更呈高渗状态。变应性鼻炎患者的鼻分泌物渗透压高于急性上呼吸道感染患者和对照组。
