Department of Emergency and Organ Transplantation, School and Chair of Allergology and Clinical Immunology, University of Bari-Aldo Moro, Bari, Italy.
Department of Medical and Surgical Sciences, School and Chair of Allergology and Clinical Immunology, University of Foggia, Foggia, Italy.
Acta Haematol. 2020;143(5):496-499. doi: 10.1159/000503768. Epub 2020 Mar 17.
Iron deficiency is the main cause of anemia in both sexes, with women being more commonly affected. Iron therapy is currently considered an effective and safe remedy to replenish the iron storages. Iron can be administrated both orally and intravenously. In particular, intravenous (IV) iron therapy is widely used when oral iron preparations are either not tolerated or ineffective. Indeed, IV iron improves iron stores more rapidly. Two main immunological responses have been described for iron hypersensitivity reactions (HSRs): IgE-mediated allergy and complement activation-related pseudo-allergy. Here, we report 3 cases of adult patients with iron allergy, who were successfully treated with two different desensitization procedures, respectively. Analysis of these cases demonstrates that, in the presence of HSRs to iron products, desensitization is an effective and safe procedure that prevents treatment discontinuation and hence allows therapeutic target achievement.
缺铁是男女贫血的主要原因，其中女性更为常见。铁剂治疗目前被认为是补充铁储存的有效和安全的方法。铁可以口服和静脉给药。特别是当口服铁制剂不耐受或无效时，广泛使用静脉内（IV）铁治疗。事实上，IV 铁可以更快地改善铁储存。已经描述了两种主要的免疫反应来解释铁超敏反应（HSR）：IgE 介导的过敏和补体激活相关假性过敏。在这里，我们报告了 3 例成人铁过敏患者，他们分别通过两种不同的脱敏程序成功治疗。对这些病例的分析表明，在存在对铁产品的 HSR 时，脱敏是一种有效和安全的方法，可以防止治疗中断，从而实现治疗目标。
