Fan Lijuan, Huang Ruihua, Wu Chengwu, Cao Yang, Du Taoran, Pu Guang, Wang Huan, Zhou Wuduo, Li Pinghua, Kim Sung Woo
Institute of Swine Science, Nanjing Agricultural University, Nanjing 210095, China.
Huaian Academy, Nanjing Agricultural University, Huaian 223003, China.
Animals (Basel). 2020 Mar 8;10(3):449. doi: 10.3390/ani10030449.
Rice bran is a waste product with low cost and high fiber content, giving it an added advantage over corn and soybean meal, which have to be purchased and always at a relatively higher cost. Under the background of increased attention to sustainable agriculture, it is significant to find alternative uses for this byproduct. A total of 35 finishing pigs were allotted to five dietary treatments: a control group with basal diet and four experimental diets where corn was equivalently substituted by 7%, 14%, 21%, and 28% defatted rice bran (DFRB), respectively. With increasing levels of DFRB, the neutrophil to lymphocyte ratio (NLR) linearly decreased ( < 0.05). In the jejunum, the mRNA level of nuclear factor erythroid-2 related factor-2 () exhibited a quadratic response ( < 0.01) with incremental levels of DFRB. In the colon, the mRNA levels of mucin 2 (), Nrf2, and NAD(P)H: quinone oxidoreductase 1 () were upregulated (linear, < 0.05) and heme oxygenase-1 () was upregulated (linear, < 0.01). Overall, using DFRB to replace corn decreased the inflammatory biomarkers of serum and showed potential function in modulating the intestinal barrier by upregulating the mRNA expression levels of and downregulating that of , , and in the colon.
米糠是一种低成本、高纤维含量的废弃物，与必须购买且成本相对较高的玉米和豆粕相比，具有额外的优势。在对可持续农业关注度不断提高的背景下，为这种副产品寻找其他用途具有重要意义。总共35头育肥猪被分配到五种日粮处理中：一个基础日粮对照组和四个试验日粮组，其中玉米分别被7%、14%、21%和28%的脱脂米糠（DFRB）等量替代。随着DFRB水平的增加，中性粒细胞与淋巴细胞比值（NLR）呈线性下降（P<0.05）。在空肠中，核因子红细胞2相关因子2（Nrf2）的mRNA水平随着DFRB水平的增加呈二次反应（P<0.01）。在结肠中，黏蛋白2（MUC2）、Nrf2和NAD（P）H：醌氧化还原酶1（NQO1）的mRNA水平上调（线性，P<0.05），血红素加氧酶-1（HO-1）上调（线性，P<0.01）。总体而言，用DFRB替代玉米可降低血清中的炎症生物标志物，并通过上调结肠中MUC2和NQO1的mRNA表达水平以及下调HO-1、Nrf2和MUC2的mRNA表达水平，在调节肠道屏障方面显示出潜在功能。
