Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Genetics, Blavantik Institute, Harvard Medical School, Boston, MA 02115, USA.
Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Genetics, Blavantik Institute, Harvard Medical School, Boston, MA 02115, USA.
Cancer Cell. 2020 Mar 16;37(3):265-267. doi: 10.1016/j.ccell.2020.02.007.
Chemotherapy remains the main treatment option for patients with several tumor types. In this issue of Cancer Cell, Salvador-Barbero et al. demonstrate that treatment with CDK4/6 inhibitors after application of taxanes (or other chemotherapeutic compounds) strongly potentiates the anti-tumor effect due to repression of DNA repair machinery.
化疗仍然是多种肿瘤类型患者的主要治疗选择。在本期《癌细胞》杂志上，Salvador-Barbero 等人证明，在应用紫杉烷（或其他化疗药物）后使用 CDK4/6 抑制剂治疗，由于抑制了 DNA 修复机制，可显著增强抗肿瘤作用。
