Lee James, Zilm Peter S, Kidd Stephen P
Department of Molecular and Biomedical Science, The University of Adelaide, Adelaide, SA, Australia.
Research Centre for Infectious Diseases, Adelaide, SA, Australia.
Front Microbiol. 2020 Feb 28;11:321. doi: 10.3389/fmicb.2020.00321. eCollection 2020.
remains a great burden on the healthcare system. Despite prescribed treatments often seemingly to be successful, can survive and cause a relapsing infection which cannot be cleared. These infections are in part due to quasi-dormant sub-population which is tolerant to antibiotics and able to evade the host immune response. These include Small Colony Variants (SCVs). Because SCVs readily revert to non-SCV cell types under laboratory conditions, the characterization of SCVs has been problematic. This mini-review covers the phenotypic and genetic changes in stable SCVs including the selection of SCVs by and interactions with other bacterial species.
仍然是医疗系统的巨大负担。尽管规定的治疗通常看似成功，但（病原体）能够存活并导致复发性感染且无法清除。这些感染部分归因于对抗生素耐受并能够逃避宿主免疫反应的准休眠亚群。这些包括小菌落变体（SCV）。由于SCV在实验室条件下很容易恢复为非SCV细胞类型，因此SCV的表征一直存在问题。这篇小型综述涵盖了稳定SCV中的表型和基因变化，包括SCV的选择以及与其他细菌物种的相互作用。
