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一位药物化学家在美国国立卫生研究院的逐分子探索之旅。

A Medicinal Chemist's Journey at the National Institutes of Health One Molecule at a Time.

作者信息

Newman Amy Hauck

机构信息

Medicinal Chemistry Section, Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse-Intramural Research Program, National Institutes of Health, 333 Cassell Drive, Baltimore, Maryland 21224, United States.

出版信息

ACS Med Chem Lett. 2020 Mar 12;11(3):221-224. doi: 10.1021/acsmedchemlett.9b00478.

DOI:10.1021/acsmedchemlett.9b00478
PMID:32184946
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7073881/
Abstract

Medicinal chemistry is a small but critical discipline that is integrated into several institutes across the National Institutes of Health, including the National Institute on Drug Abuse. I have had the opportunity and privilege to contribute novel small molecules that have opened opportunities for drug discovery, especially targeted to underserved populations who suffer from substance use disorders.

摘要

药物化学是一门规模虽小但至关重要的学科，它融入了美国国立卫生研究院的多个机构，包括国家药物滥用研究所。我有幸贡献了一些新型小分子，为药物研发带来了机遇，特别是针对那些患有物质使用障碍却未得到充分治疗的人群。

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Novel 1-phenylcycloalkanecarboxylic acid derivatives as potential anticonvulsant agents.新型1-苯基环烷羧酸衍生物作为潜在的抗惊厥剂。
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