Kurisu Satoshi, Nitta Kazuhiro, Ikenaga Hiroki, Ishibashi Ken, Fukuda Yukihiro, Kihara Yasuki
Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences, 1-2-3, Kasumi-cho, Minami-ku, Hiroshima, 734-8551, Japan.
Heart Vessels. 2020 Aug;35(8):1095-1101. doi: 10.1007/s00380-020-01585-1. Epub 2020 Mar 18.
The frontal QRS-T angle, defined as the angle between QRS and T-wave axes, has recently become an area of research interest. We tested the hypothesis that the frontal QRS-T angle is associated with left ventricular (LV) diastolic function in the absence of significant perfusion abnormality using ECG-gated SPECT. One hundred twenty eight patients with no significant perfusion abnormality and preserved LV ejection fraction were enrolled. The peak filling rate (PFR) and the one-third mean filling rate (1/3 MFR) were obtained as LV diastolic parameters on ECG-gated SPECT. There were 115 male and 13 female patients with a mean age of 70 ± 9 years. The PFR and 1/3 MFR were 2.1 ± 0.4/s and 1.2 ± 0.3/s, respectively. The frontal QRS-T angle was 33° ± 31°, ranging from 0° to 151°. There were significant associations of frontal QRS-T angle with PFR (r = - 0.29, p = 0.001) and 1/3 MFR (r = - 0.30, p < 0.001). Multivariate linear regression analysis showed that age (β = - 0.25, p = 0.003), heart rate (β = 0.26, p = 0.002), LV ejection fraction (β = 0.43, p < 0.001) and frontal QRS-T angle (β = - 0.16, p = 0.03) were significant factors associated with PFR. Also, heart rate (β = - 0.32, p < 0.001), LV mass index (β = - 0.19, p = 0.03), LV ejection fraction (β = 0.30, p < 0.001) and frontal QRS-T angle (β = - 0.26, p = 0.002) were significant factors associated with 1/3 MFR. Our data suggested that the frontal QRS-T angle was associated with LV diastolic function in the absence of significant perfusion abnormality.
额面QRS-T角定义为QRS波与T波轴之间的夹角，最近已成为一个研究热点。我们检验了这样一个假设：在无明显灌注异常的情况下，额面QRS-T角与左心室（LV）舒张功能相关。本研究纳入了128例无明显灌注异常且左心室射血分数保留的患者。通过心电图门控单光子发射计算机断层扫描（ECG-gated SPECT）获取左心室舒张参数，即峰值充盈率（PFR）和三分之一平均充盈率（1/3 MFR）。患者中有115例男性和13例女性，平均年龄为70±9岁。PFR和1/3 MFR分别为2.1±0.4/s和1.2±0.3/s。额面QRS-T角为33°±31°，范围从0°至151°。额面QRS-T角与PFR（r = - 0.29，p = 0.001）和1/3 MFR（r = - 0.30，p < 0.001）之间存在显著相关性。多变量线性回归分析显示，年龄（β = - 0.25，p = 0.003）、心率（β = 0.26，p = 0.002）、左心室射血分数（β = 0.43，p < 0.001）和额面QRS-T角（β = - 0.16，p = 0.03）是与PFR相关的显著因素。此外，心率（β = - 0.32，p < 0.001）、左心室质量指数（β = - 0.19，p = 0.03）、左心室射血分数（β = 0.30，p < 0.001）和额面QRS-T角（β = - 0.26，p = 0.002）是与1/3 MFR相关的显著因素。我们的数据表明，在无明显灌注异常的情况下，额面QRS-T角与左心室舒张功能相关。
