Kang Min Jong
Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA.
Tuberc Respir Dis (Seoul). 2020 Apr;83(2):107-115. doi: 10.4046/trd.2020.0003. Epub 2020 Mar 10.
Aging is often viewed as a progressive decline in fitness due to cumulative deleterious alterations of biological functions in the living system. Recently, our understanding of the molecular mechanisms underlying aging biology has significantly advanced. Interestingly, many of the pivotal molecular features of aging biology are also found to contribute to the pathogenesis of chronic lung disorders such as chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis, for which advanced age is the most crucial risk factor. Thus, an enhanced understanding of how molecular features of aging biology are intertwined with the pathobiology of these aging-related lung disorders has paramount significance and may provide an opportunity for the development of novel therapeutics for these major unmet medical needs. To serve the purpose of integrating molecular understanding of aging biology with pulmonary medicine, in this review, recent findings obtained from the studies of aging-associated lung disorders are summarized and interpreted through the perspective of molecular biology of aging.
衰老通常被视为由于生命系统中生物功能的累积有害改变而导致的健康状况逐渐下降。最近，我们对衰老生物学潜在分子机制的理解有了显著进展。有趣的是，衰老生物学的许多关键分子特征也被发现与慢性肺部疾病如慢性阻塞性肺疾病和特发性肺纤维化的发病机制有关，而高龄是这些疾病最关键的危险因素。因此，深入了解衰老生物学的分子特征如何与这些衰老相关肺部疾病的病理生物学相互交织具有至关重要的意义，并可能为满足这些重大未满足医疗需求开发新型疗法提供机会。为了将衰老生物学的分子理解与肺医学相结合，在本综述中，从衰老相关肺部疾病研究中获得的最新发现将通过衰老分子生物学的视角进行总结和解读。
