He X, Schmidt R F, Schmittner H
Physiologisches Institut, Universität Würzburg, FRG.
Agents Actions. 1988 Dec;25(3-4):222-4. doi: 10.1007/BF01965017.
This study on the effects of capsaicin on primary afferents from normal knee joints of the cat was performed to further elucidate the mechanisms of articular pain evoked by an acute arthritis and by chemical irritants. It showed that close i.a. bolus injection of capsaicin (10(-7)-10(-4) M) excites most fine articular afferents (conduction velocity less than or equal to 11.3 m/s) whereas fast units are not excited. Fine afferents with low to medium thresholds to knee joint movement are less readily excited by capsaicin than high threshold ones. The response to capsaicin is usually a rapid burst of impulses of a very short latency. This response pattern differs considerably from that seen after application of endogenous substances produced in inflammation. Thus capsaicin seems to differ in its mode of action from that of endogenous algesic substances.
进行这项关于辣椒素对猫正常膝关节初级传入神经影响的研究，是为了进一步阐明急性关节炎和化学刺激物引起关节疼痛的机制。研究表明，关节内近距离推注辣椒素（10^(-7)-10^(-4)M）可兴奋大多数细关节传入神经（传导速度小于或等于11.3m/s），而快速传导的单位则不被兴奋。对膝关节运动阈值低至中等的细传入神经比高阈值的细传入神经更不容易被辣椒素兴奋。对辣椒素的反应通常是潜伏期极短的快速冲动爆发。这种反应模式与炎症中产生的内源性物质作用后所见的模式有很大不同。因此，辣椒素的作用方式似乎与内源性致痛物质不同。
