Respiratary Department of Pi Du District Hopspital of Traditional Chinese Medicine, Chengdu 611730, China.
Research Department of Pi Du District Hopspital of Traditional Chinese Medicine, Chengdu 611730, China.
J Tradit Chin Med. 2018 Oct;38(5):661-667.
To assess the curative effect of Traditional Chinese Medicine (TCM) on leukopenia induced by chemo-radiotherapy in patients with lung cancer.
A comprehensive electronic search in Medline, Embase, the Cochrane Libary database, China National Knowledge Infrastructure Database (CNKI) and Wanfang Database was conducted up to July 2017. Random-effects model was used to estimate the standardized mean differences (SMDs) with 95% confidence intervals (CIs). Eleven studies with a total of 957 patients were included in this meta-analysis.
The effectiveness in TCM group was higher than control group [RR = 1.60, 95% CI (1.38, 1.85), P < 0.000 01]. Compare with Western Medicine group, the effectiveness has no significant difference [RR = 0.96, 95% CI (0.82, 1.12), P = 0.57]. The ineffective rate in test group was lower than the control group [RR = 0.30, 95% CI (0.21, 0.42), P < 0.000 01].
By meta-regression it was suggested that TCM has curative effect on leukopenia induced by chemo-radiotherapy in patients with lung cancer, but by the influence of number and quality of researches, publication bias, more evidence from high quality studies, and larger cohorts for observational trials are needed.
评估中医药治疗肺癌放化疗所致白细胞减少症的疗效。
检索 Medline、Embase、Cochrane 图书馆、中国知网（CNKI）和万方数据库，检索时限均为 2017 年 7 月前。采用随机效应模型，计算标准化均数差（SMD）及其 95%置信区间（95%CI）。对纳入的 11 项研究进行荟萃分析，共 957 例患者。
与对照组相比，中医药组的疗效更高[RR=1.60，95%CI（1.38，1.85），P<0.00001]。与西药组相比，中医药组的疗效无显著差异[RR=0.96，95%CI（0.82，1.12），P=0.57]。试验组的无效率低于对照组[RR=0.30，95%CI（0.21，0.42），P<0.00001]。
荟萃回归分析表明，中医药对肺癌放化疗所致白细胞减少症有疗效，但受研究数量和质量、发表偏倚的影响，需要更多高质量研究和更大样本的观察性试验来进一步证实。
