First Clinical Medical School of Beijing University of Chinese Medicine, Beijing 100700, China.
Traditional Chinese Medicine Gynecology Department, China-Japan Friendship Hospital, Beijing 100029, China.
J Tradit Chin Med. 2019 Jun;39(3):440-450.
To research the Traditional Chinese Medicine (TCM) practice of Professor Xu Runsan for treatment of chronic pelvic pain (CPP) caused by sequelae of pelvic inflammatory disease (SPID) by data mining.
The medical records of inpatients at China-Japan Friendship Hospital confirmed to have CPP caused by SPID were collected (274 visits in total). The data extracted from the medical records were analyzed by frequency statistics, correlation analyses, cluster analyses, and complex network analyses.
The most frequently used medicines were warm medicines, bitter medicines, and medicines distributed to the liver meridian. The most common medicinal combinations were Chishao (Radix Paeoniae Rubra) plus Huangqi (Radix Astragali Mongolici) plus Sanqi (Radix Notoginseng) and Ezhu (Rhizoma Curcumae Phaeocaulis); Guizhi (Ramulus Cinnamomi) plus Fuling (Poria) and Chishao (Radix Paeoniae Rubra); and Chaihu (Radix Bupleuri Chinensis) plus Zhishi (Fructus Aurantii Immaturus) and Gancao (Radix Glycyrrhizae). The most frequently used medicines were divided into four groups according to their efficacy; i.e., medicines that could (a) warm meridians and free collateral vessels, (b) regulate Qi and free collateral vessels, (c) fortify the spleen and nourish blood and Qi, and (d) tonify Qi and activate blood. The most commonly used formulations were Guizhi FulingPill and Sini Powder. The core medicines extracted based on complex network analyses were Chishao (Radix Paeoniae Rubra), Sanqi (Radix Notoginseng), Huangqi (Radix Astragali Mongolici), Danshen (Radix Salviae Miltiorrhizae), Ezhu (Rhizoma Curcumae Phaeocaulis), Gancao (Radix Glycyrrhizae), Chaihu (Radix Bupleuri Chinensis), Guizhi (Ramulus Cinnamomi), Shuizhi (Hirudo), Fuling (Poria), and Zhishi (Fructus Aurantii Immaturus).
According to the TCM practice of Professor Xu, treatment of CPP caused by SPID should focus on dissolving stasis and obstructionsusing medicines that can activate blood, resolve stasis, regulate Qi, and dissipate adhesions. His prescriptions are often based on Guizhi Fuling Pill and Sini Powder. More blood-activating, stasis-resolving, or tonifying medicines could be used according to the accompanying symptoms or symptom patterns identified.
通过数据挖掘研究许润三教授治疗盆腔炎后遗症慢性盆腔痛（CPP）的中医实践。
收集中国-日本友好医院确诊为 CPP 且由 SPID 引起的住院患者的病历（共 274 次就诊）。从病历中提取的数据进行频率统计、相关性分析、聚类分析和复杂网络分析。
最常用的药物是温药、苦药和入肝经的药物。最常见的药物组合是赤芍加黄芪加三七和莪术；桂枝加茯苓和赤芍；柴胡加枳实和甘草。最常用的药物根据其功效分为四组；即能（a）温经通络，（b）调气通络，（c）健脾养血益气，（d）益气活血的药物。最常用的方剂是桂枝茯苓丸和四逆散。基于复杂网络分析提取的核心药物有赤芍、三七、黄芪、丹参、莪术、甘草、柴胡、桂枝、水蛭、茯苓、枳实。
根据许润三教授的中医实践，治疗 SPID 引起的 CPP 应注重活血化瘀、调气散结。他的处方常以桂枝茯苓丸和四逆散为基础。根据伴随症状或症状模式，可以使用更多的活血、化瘀或补气的药物。
