Pintér E, Szolcsànyi J
Department of Pharmacology, University Medical School of Pécs, Hungary.
Agents Actions. 1988 Dec;25(3-4):240-2. doi: 10.1007/BF01965023.
Unilateral antidromic stimulation of the rat's lumbar dorsal roots evoked plasma extravasation in the skin of the corresponding hindpaw. Identical antidromic stimulation of the contralateral dorsal roots 4-5 minutes prior to the stimulation inhibited this response by 49%. No inhibition occurred when time interval between the stimulations was 60 minutes. It is concluded that not only inflammatory, but antiinflammatory mediators are released in response to activation of the peripheral endings of primary afferent neurons.
对大鼠腰背部背根进行单侧逆向刺激，可诱发相应后爪皮肤出现血浆外渗。在刺激前4 - 5分钟对侧背根进行相同的逆向刺激，可使该反应受到49%的抑制。当刺激间隔时间为60分钟时，未出现抑制现象。由此得出结论，不仅炎症介质，而且抗炎介质也会在初级传入神经元外周末梢激活时释放。
