Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), Raebareli, Lucknow, Uttar Pradesh, India.
Crit Rev Toxicol. 2020 Jan;50(1):47-71. doi: 10.1080/10408444.2020.1726282. Epub 2020 Mar 18.
Zinc oxide nanoparticles are well-known metal oxide nanoparticles having numbers of applications in the field of cosmetology, medicine, and chemistry. However, the number of reports has indicated its toxicity also such as hepatotoxicity, pulmonary toxicity, neurotoxicity, and immunotoxicity. Thus, in this article, we have analyzed the potential risks and benefits of zinc oxide nanoparticles. The data related to risks and benefits of zinc oxide nanoparticles have been extracted from PubMed (from January 2007 to August 2019). A total of 3,892 studies have been published during this period regarding zinc oxide nanoparticles. On the basis of inclusion and exclusion criteria, 277 studies have been included for the analysis of risks and benefits. Emerging reports have indicated both risks and benefits of zinc oxide nanoparticles in concentration- and time-dependent manner under and conditions through different mechanism of action. In conclusion, zinc oxide nanoparticles could play a beneficial role in the treatment of various diseases but safety of these particles at particular effective concentration should be thoroughly evaluated.
氧化锌纳米粒子是众所周知的金属氧化物纳米粒子，在化妆品、医学和化学领域有许多应用。然而，大量的报告表明它也具有毒性，如肝毒性、肺毒性、神经毒性和免疫毒性。因此，在本文中，我们分析了氧化锌纳米粒子的潜在风险和益处。与氧化锌纳米粒子的风险和益处相关的数据是从 PubMed 中提取的（从 2007 年 1 月到 2019 年 8 月）。在此期间，共发表了 3892 篇关于氧化锌纳米粒子的研究。根据纳入和排除标准，有 277 项研究被纳入风险和益处的分析。新兴的报告表明，在 和 条件下，氧化锌纳米粒子通过不同的作用机制，以浓度和时间依赖的方式表现出风险和益处。总之，氧化锌纳米粒子在治疗各种疾病方面可能发挥有益的作用，但应彻底评估这些颗粒在特定有效浓度下的安全性。
