State Key Laboratory of Silicon Materials, School of Materials Science and Engineering, Zhejiang University, 310027, China.
Chem Commun (Camb). 2020 Apr 21;56(31):4304-4307. doi: 10.1039/d0cc00763c. Epub 2020 Mar 18.
For the first time, we report the design and fabrication of a ZnS nanoparticle-decorated silica fibre mesh (ZnS@SiO) for localized HS-amplified chemotherapy. With incorporation of DOX, implanted ZnS@SiO fibres enable sufficient on-site drug dosage and intracellular HS content, inducing significant in vitro and in vivo tumour inhibition.
我们首次报告了一种 ZnS 纳米粒子修饰的二氧化硅纤维网（ZnS@SiO）的设计和制造，用于局部 HS 增强化疗。通过掺入 DOX，植入的 ZnS@SiO 纤维能够实现足够的局部药物剂量和细胞内 HS 含量，从而在体外和体内显著抑制肿瘤。
