一种具有乳腺癌干细胞活性的三金属钯配合物。
A tri-metallic palladium complex with breast cancer stem cell potency.
机构信息
School of Pharmacy, University College London, London, UK.
Department of Chemistry, Gauhati University, Guwahati, India.
出版信息
Dalton Trans. 2020 Apr 7;49(14):4211-4215. doi: 10.1039/d0dt00006j.
PMID:32186576
Abstract
A multi-nuclear, triangular-shaped palladium(ii) complex is shown to equipotently kill bulk cancer cells and cancer stem cells (CSCs) in the micromolar range. The palladium(ii) complex evokes CSC apoptosis by entering CSC nuclei and damaging genomic DNA.
摘要
一种多核、三角形钯（ii）配合物在微摩尔范围内被证明能够有效地杀死大量癌细胞和癌症干细胞（CSCs）。钯（ii）配合物通过进入 CSC 核并损伤基因组 DNA 来引发 CSC 细胞凋亡。
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