Department of Psychiatry and Behavioral Neuroscience, The University of Chicago.
Department of Child Health, University of Missouri School of Medicine, Columbia, Missouri.
J Pers Disord. 2020 Mar;34(Suppl):6-24. doi: 10.1521/pedi.2020.34.supp.6.
The authors hypothesized that personality disorders characterized by interpersonal hypersensitivity would be associated with an elevated concentration of 8-hydroxy-2'-deoxyguanosine (8-OH-DG), the oxidized form of guanine, and a biomarker of oxidative stress burden. One hundred ninety-five male and female adults underwent semistructured diagnostic interviews, completed questionnaire measures of social cognition and emotional attribution, and had blood drawn for determination of plasma 8-OH-DG. A hierarchical linear regression model revealed that narcissistic and borderline personality disorders predicted 8-OH-DG level independently of the effects of age, gender, recent alcohol and cigarette use, current major depression, and posttraumatic stress disorder. In all subjects, 8-OH-DG level was also correlated with the number of borderline personality disorder symptoms present. Narcissistic and borderline personality disorders predicted oxidative stress burden independently of potentially confounding factors.
研究人员假设，人际敏感特征明显的人格障碍与 8-羟基-2'-脱氧鸟苷（8-OH-DG）的浓度升高有关，8-OH-DG 是鸟嘌呤的氧化形式，也是氧化应激负担的生物标志物。195 名男性和女性成年人接受了半结构化诊断访谈，完成了社会认知和情绪归因的问卷测量，并抽取血液以确定血浆 8-OH-DG 水平。分层线性回归模型显示，自恋型和边缘型人格障碍独立于年龄、性别、近期烟酒使用、当前重度抑郁症和创伤后应激障碍的影响，预测了 8-OH-DG 水平。在所有受试者中，8-OH-DG 水平也与边缘型人格障碍症状的数量呈正相关。自恋型和边缘型人格障碍独立于潜在的混杂因素预测了氧化应激负担。
