颏舌肌摄取氟脱氧葡萄糖：一个常见的误区。

Fluoro-deoxy-glucose uptake in the mylohyoid muscle: a common misconception.

机构信息

Department of Nuclear Medicine.

Department of Otorhinolaryngology, Head & Neck Surgery, University Hospital Zurich, University of Zurich, Zurich, Switzerland.

出版信息

Nucl Med Commun. 2020 May;41(5):452-458. doi: 10.1097/MNM.0000000000001174.

DOI:10.1097/MNM.0000000000001174

PMID:32187162

Abstract

AIM

The mylohyoid muscle is often believed to exhibit high physiologic fluoro-deoxy-glucose (FDG) uptake. Aim of this study was to use PET/MR for adequately assessing the normal FDG distribution in floor of the mouth (FOM) muscles and neighboring major salivary glands.

MATERIALS AND METHODS

Patients scanned with a simultaneous PET/MRI system for initial staging or follow-up of head and neck tumors, with no malignant lesions in salivary glands or in FOM, were included. Volumes-of-interest (VOIs) were positioned separately for bilateral mylohyoid, digastric, genioglossus, and geniohyoid muscles, based on T2-weighted and T1-weighted images, and for bilateral parotid, submandibular, and sublingual glands in the same way. SUVmax was measured for each VOI.

RESULTS

Six hundred and ninety-two VOIs were positioned. FDG uptake in mylohyoid (SUVmax = 1.94 ± 0.37) and digastric muscles (SUVmax = 2.01 ± 0.37) were significantly higher compared to that in geniohyoid (SUVmax = 1.67 ± 0.53) and genioglossus muscles (SUVmax = 1.75 ± 0.54) (Friedman's test; P < 0.001). FDG uptake in the sublingual glands (SUVmax = 3.77 ± 1.63) was significantly higher compared to the parotid glands (SUVmax = 2.34 ± 0.60) and submandibular glands (SUVmax = 2.51 ± 0.59) (Wilcoxon signed-ranks test; P < 0.001). FDG uptake in sublingual glands was significantly higher than FDG uptake in the mylohyoid muscles (P < 0.001). FDG uptake in the parotid, submandibular, and sublingual glands was inversely correlated to the age of subjects (Spearman' rho coefficient: -0.397/P = 0.004; -0.329/P = 0.021; -0.535/P < 0.001, respectively).

CONCLUSION

The sublingual glands yield the highest physiologic FDG uptake in the FOM. High FDG uptake in the mylohyoid muscle is a common misconception.

摘要

目的

人们普遍认为颏舌骨肌的氟代脱氧葡萄糖（FDG）摄取具有较高的生理活性。本研究旨在使用 PET/MR 充分评估口底（FOM）肌肉和相邻主要唾液腺的正常 FDG 分布。

材料与方法

本研究纳入了在头部和颈部肿瘤初始分期或随访时使用同时进行的 PET/MRI 系统进行扫描的患者，这些患者的唾液腺或 FOM 中无恶性病变。根据 T2 加权像和 T1 加权像，分别为双侧颏舌骨肌、二腹肌、颏舌肌和颏舌骨肌定位容积感兴趣区（VOI），并以同样的方式为双侧腮腺、颌下腺和舌下腺定位 VOI。测量每个 VOI 的最大标准摄取值（SUVmax）。

结果

共定位了 692 个 VOI。与颏舌骨肌（SUVmax=1.67±0.53）和二腹肌（SUVmax=2.01±0.37）相比，颏舌肌（SUVmax=1.94±0.37）和二腹肌（SUVmax=2.01±0.37）的 FDG 摄取明显更高，与舌骨肌（SUVmax=1.75±0.54）和舌骨肌（SUVmax=1.75±0.54）的 FDG 摄取也更高（Friedman 检验；P<0.001）。与腮腺（SUVmax=2.34±0.60）和颌下腺（SUVmax=2.51±0.59）相比，舌下腺（SUVmax=3.77±1.63）的 FDG 摄取明显更高（Wilcoxon 符号秩检验；P<0.001）。与颏舌骨肌相比，舌下腺的 FDG 摄取明显更高（P<0.001）。腮腺、颌下腺和舌下腺的 FDG 摄取与受试者年龄呈负相关（Spearman rho 系数：-0.397/P=0.004；-0.329/P=0.021；-0.535/P<0.001）。