Laboratory of Comparative Ethology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland.
Psychology Department, Nottingham Trent University, Nottingham, UK.
Am J Primatol. 2020 May;82(5):e23122. doi: 10.1002/ajp.23122. Epub 2020 Mar 18.
The Brazelton Neonatal Behavioral Assessment Scale (NBAS) evaluates a newborn infant's autonomic, motor, state, temperament, and social-attentional systems, which can help to identify infants at risk of developmental problems. Given the prevalence of rhesus monkeys being used as an animal model for human development, here we aimed to validate a standardized test battery modeled after the NBAS for use with nonhuman primates called the Infant Behavioral Assessment Scale (IBAS), employing exploratory structural equation modeling using a large sample of rhesus macaque neonates (n = 1,056). Furthermore, we examined the repeated assessments of the common factors within the same infants to describe any changes in performance over time, taking into account two independent variables (infant sex and rearing condition) that can potentially affect developmental outcomes. Results revealed three factors (Orientation, State Control, and Motor Activity) that all increased over the 1st month of life. While infant sex did not have an effect on any factor, nursery-rearing led to higher scores on Orientation but lower scores on State Control and Motor Activity. These results validate the IBAS as a reliable and valuable research tool for use with rhesus macaque infants and suggest that differences in rearing conditions can affect developmental trajectories and potentially pre-expose infants to heightened levels of cognitive and emotional deficiencies.
布雷泽顿新生儿行为评估量表（NBAS）评估新生儿的自主、运动、状态、气质和社会注意力系统，有助于识别有发育问题风险的婴儿。鉴于恒河猴被广泛用作人类发育的动物模型，我们旨在为非人类灵长类动物（猕猴）验证一种经过 NBAS 标准化的测试工具，称为婴儿行为评估量表（IBAS），使用探索性结构方程建模对大量恒河猴新生儿（n=1056）进行评估。此外，我们还检查了同一婴儿中常见因素的重复评估，以描述随着时间推移性能的任何变化，并考虑了两个可能影响发育结果的独立变量（婴儿性别和饲养条件）。结果显示，有三个因素（定向、状态控制和运动活动）在生命的第一个月都有所增加。虽然婴儿性别对任何因素都没有影响，但在托儿所饲养会导致定向得分较高，而状态控制和运动活动得分较低。这些结果验证了 IBAS 作为一种可靠且有价值的研究工具，可用于猕猴婴儿，并表明饲养条件的差异会影响发育轨迹，并可能使婴儿提前面临认知和情感缺陷的风险。
