非人类灵长类动物在神经毒理学研究中的作用：临床前模型与实验方法。
The Role of Nonhuman Primates in Neurotoxicology Research: Preclinical Models and Experimental Methods.
机构信息
Department of Environmental & Occupational Health Sciences (DEOHS), University of Washington, Seattle, Washington.
出版信息
Curr Protoc. 2023 Mar;3(3):e698. doi: 10.1002/cpz1.698.
Although noteworthy progress has been made in developing alternatives to animal testing, nonhuman primates still play a critical role in advancing biomedical research and will likely do so for many years. Core similarities between monkeys and humans in genetics, physiology, reproduction, development, and behavior make them excellent models for translational studies relevant to human health. This unit is designed to specifically address the role of nonhuman primates in neurotoxicology research and outlines the specialized assessments that can be used to measure exposure-related changes at the structural, chemical, cellular, molecular, and functional levels. © 2023 Wiley Periodicals LLC.
尽管在开发替代动物测试的方法方面取得了显著进展，但非人类灵长类动物在推进生物医学研究方面仍发挥着关键作用，并且在未来许多年内可能仍将如此。猴子和人类在遗传学、生理学、生殖、发育和行为方面存在核心相似性，这使它们成为与人类健康相关的转化研究的优秀模型。本单元专门探讨了非人类灵长类动物在神经毒理学研究中的作用，并概述了可用于测量结构、化学、细胞、分子和功能水平与暴露相关的变化的特殊评估方法。 © 2023 Wiley Periodicals LLC.
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