铱催化乙二醇和甲醇选择性交叉偶联合成乳酸。
Iridium-Catalyzed Selective Cross-Coupling of Ethylene Glycol and Methanol to Lactic Acid.
机构信息
Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Department of Chemistry, Fudan University, 2005 Songhu Road, Shanghai, 200438, P. R. China.
Collaborative Innovation Center of Chemistry for Energy Materials MOE Laboratory for Computational Physical Science, Fudan University, 2005 Songhu Road, Shanghai, 200438, P. R. China.
出版信息
Angew Chem Int Ed Engl. 2020 Jun 22;59(26):10421-10425. doi: 10.1002/anie.202002403. Epub 2020 Apr 7.
An atom-economic approach that has an unprecedented high selectivity for the synthesis of lactic acid (LA) based on a catalytic dehydrogenative cross-coupling by using inexpensive bulk ethylene glycol and methanol is described. This method relies on the synthesis and utilization of a novel iridium catalyst bearing three N-heterocyclic carbenes derived from 1,3-dimethylbenzimidazolium salts, and exhibits outstanding activity in the production of LA [turnover frequency (TOF) up to 3660 h ] owing to an elegant metal-ligand cooperation.
本文描述了一种原子经济性方法，该方法具有前所未有的高选择性，可通过使用廉价的大宗乙二醇和甲醇进行催化脱氢交叉偶联来合成乳酸（LA）。该方法依赖于新型铱催化剂的合成和利用，该催化剂含有三种源自 1,3-二甲基苯并咪唑𬭩盐的 N-杂环卡宾，由于其独特的金属-配体协同作用，该催化剂在 LA 的生产中表现出极高的活性[周转频率（TOF）高达 3660 h]。
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