Department of Neurology, Leiden University Medical Center, Leiden, the Netherlands.
Department of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands.
Cephalalgia. 2020 Aug;40(9):913-923. doi: 10.1177/0333102420912725. Epub 2020 Mar 18.
Migraine is associated with altered sensory processing and cortical responsivity that may contribute to susceptibility to attacks by changing brain network excitability dynamics. To gain better insight into cortical responsivity changes in migraine we subjected patients to a short series of light inputs over a broad frequency range ("chirp" stimulation), designed to uncover dynamic features of visual cortex responsivity.
EEG responses to visual chirp stimulation (10-40 Hz) were measured in controls (n = 24) and patients with migraine with aura (n = 19) or migraine without aura (n = 20). Average EEG responses were assessed at (i) all EEG frequencies between 5 and 125 Hz, (ii) stimulation frequencies, and (iii) harmonic frequencies. We compared average responses in a low (10-18 Hz), medium (19-26 Hz) and high (27-40 Hz) frequency band.
Responses to chirp stimulation were similar in controls and migraine subtypes. Eight measurements (n = 3 migraine with aura; n = 5 without aura) were assigned as "pre-ictal", based on reported headache within 48 hours after investigation. Pre-ictally, an increased harmonic response to 22-32 Hz stimulation (beta band) was observed ( = 0.001), compared to interictal state measurements.
We found chirp responses to be enhanced in the 48 hours prior to migraine headache onset. Visual chirp stimulation proved a simple and reliable technique with potential to detect changes in cortical responsivity associated with the onset of migraine attacks.
偏头痛与感觉处理和皮质反应性改变有关，这些改变可能通过改变大脑网络兴奋性动力学来增加对攻击的易感性。为了更好地了解偏头痛患者皮质反应性的变化，我们对患者进行了一系列短时间的宽频范围的光刺激（“啁啾”刺激），旨在揭示视觉皮层反应性的动态特征。
在对照组（n=24）和有先兆偏头痛患者（n=19）或无先兆偏头痛患者（n=20）中测量视觉啁啾刺激（10-40 Hz）的 EEG 反应。平均 EEG 反应在以下三种情况下进行评估：（i）5 到 125 Hz 之间的所有 EEG 频率；（ii）刺激频率；（iii）谐波频率。我们比较了低频（10-18 Hz）、中频（19-26 Hz）和高频（27-40 Hz）带宽内的平均反应。
啁啾刺激的反应在对照组和偏头痛亚型中相似。根据调查后 48 小时内报告的头痛，有 8 次测量（n=3 例有先兆偏头痛；n=5 例无先兆偏头痛）被归类为“先兆期”。与间歇期测量相比，观察到 22-32 Hz 刺激（β频带）的谐波反应增强（ =0.001）。
我们发现偏头痛头痛发作前 48 小时内啁啾反应增强。视觉啁啾刺激是一种简单可靠的技术，具有检测与偏头痛发作相关的皮质反应性变化的潜力。
