Division of Otolaryngology-Head & Neck Surgery, Cedars-Sinai Sinus Center, Los Angeles, California.
Rhinology, Sinus & Skull Base, Kentuckiana Ear, Nose, & Throat, Department of Otolaryngology-Head & Neck Surgery, University of Louisville, Louisville, Kentucky.
Am J Rhinol Allergy. 2020 Jul;34(4):532-536. doi: 10.1177/1945892420912366. Epub 2020 Mar 18.
Chronic rhinosinusitis (CRS) has long been a suspected risk factor for Eustachian tube dysfunction (ETD). However, there have been few studies quantifying the presence of ETD in CRS patients. We sought to determine the prevalence of ETD symptoms in patients undergoing functional endoscopic sinus surgery (FESS) for CRS using the validated 7-item Eustachian Tube Dysfunction Questionnaire (ETDQ-7) and to correlate the ETDQ-7 scores with scores of CRS symptom severity based on the 22-item Sino-Nasal Outcome Test (SNOT-22).
Patients for FESS were preoperatively administered both the ETDQ-7 and the SNOT-22 validated quality of life instruments. Pearson and Spearman correlation coefficients were calculated. Changes in ETDQ-7 were measured at 3 months and differences were compared via paired test.
A total of 82 patients completed the surveys. Thirty-nine (47.6%) patients had ETDQ-7 score ≥14.5, signifying clinically significant ETD symptoms. The mean ETDQ-7 score of the study population was 15.8 ± 8.8, and the mean SNOT-22 score was 37.5 ± 19.7. The Pearson and Spearman correlation coefficients between ETDQ-7 and the total SNOT-22 score were 0.52 ( > .0001) and 0.51 ( < .0001), respectively. There was significant improvement in ETDQ-7 scores postoperatively.
While the association between ETD and CRS has long been known, this is one of the few prospective patient studies evaluating otologic symptoms in a CRS population. We found that a significant percentage of CRS patients suffer from ETD symptoms based on patient-reported subjective outcome measures. This study demonstrates that otologic symptoms increase with CRS severity and improve after FESS.
慢性鼻-鼻窦炎（CRS）长期以来一直被怀疑是咽鼓管功能障碍（ETD）的危险因素。然而，很少有研究量化 CRS 患者中 ETD 的存在。我们试图使用经过验证的 7 项咽鼓管功能障碍问卷（ETDQ-7）来确定接受功能性内镜鼻窦手术（FESS）治疗 CRS 的患者中 ETD 症状的患病率，并将 ETDQ-7 评分与基于 22 项鼻-鼻窦结局测试（SNOT-22）的 CRS 症状严重程度评分相关联。
对接受 FESS 的患者术前进行 ETDQ-7 和 SNOT-22 这两种经过验证的生活质量工具的评估。计算 Pearson 和 Spearman 相关系数。通过配对 t 检验比较 3 个月时 ETDQ-7 的变化。
共有 82 例患者完成了调查。39 例（47.6%）患者的 ETDQ-7 评分≥14.5，表明存在有临床意义的 ETD 症状。研究人群的平均 ETDQ-7 评分为 15.8±8.8，SNOT-22 总分为 37.5±19.7。ETDQ-7 与 SNOT-22 总分之间的 Pearson 和 Spearman 相关系数分别为 0.52（>0.0001）和 0.51（<0.0001）。术后 ETDQ-7 评分显著改善。
虽然 ETD 和 CRS 之间的关联早已为人所知，但这是为数不多的几项前瞻性患者研究之一，评估 CRS 人群中的耳科学症状。我们发现，根据患者报告的主观结果测量，相当一部分 CRS 患者患有 ETD 症状。本研究表明，耳科学症状随 CRS 严重程度的增加而增加，并在 FESS 后改善。
