University of Rochester Medical Center, Rochester, NY, USA.
Int J Surg Pathol. 2020 Sep;28(6):691-695. doi: 10.1177/1066896920912826. Epub 2020 Mar 18.
Glomus tumor is a rare mesenchymal neoplasm originating from the modified smooth muscle cells of the glomus body. Primary colonic glomus tumor is extremely rare with only 5 cases published in the English literature. In this article, we report the sixth case of primary colonic glomus tumor in a 50-year-old female with no significant past medical history who presented with routine screening colonoscopy. The entire colon was endoscopically unremarkable except an incidental 6-mm sessile polyp located in the descending colon. Biopsy showed a densely cellular neoplasm composed of small, bland, slightly spindled to predominantly epithelioid cells with clear to eosinophilic cytoplasm arranged in nests and sheets. The tumor cells were interspersed with slit-like thin-walled vessels and scattered short nerve bundles. Immunohistochemically, the tumor cells were positive for smooth muscle actin, h-caldesmon, and CD34 (focal), but completely negative for HMB45, S100, EMA, desmin, DOG-1, and CD117. The histologic features and immunohistochemical profile supported a diagnosis of primary colonic glomus tumor. The patient was asymptomatic and disease free after the procedure.
血管球瘤是一种罕见的间叶性肿瘤，来源于血管球的平滑肌细胞。原发性结肠血管球瘤极为罕见，英文文献中仅报道了 5 例。本文报道了第六例 50 岁女性原发性结肠血管球瘤病例，该患者无明显既往病史，因常规筛查行结肠镜检查。全结肠内镜下未见明显异常，仅见一位于降结肠的 6mm 无蒂息肉。活检显示为密集细胞性肿瘤，由小而温和、轻度梭形至主要上皮样细胞组成，细胞胞质透明或嗜酸性，呈巢状和片状排列。肿瘤细胞间散在有缝隙样薄壁血管和分散的短神经束。免疫组化染色显示肿瘤细胞 SMA、h-caldesmon 和 CD34（局灶性）阳性，而 HMB45、S100、EMA、结蛋白、DOG-1 和 CD117 均阴性。组织学特征和免疫组化表型支持原发性结肠血管球瘤的诊断。该患者术后无症状，无疾病残留。
