支持猴多瘤病毒 40 VP4 作为后期表达的病毒孔蛋白。
In Support of Simian Polyomavirus 40 VP4 as a Later Expressed Viroporin.
机构信息
Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA
Department of Biochemistry and Molecular Biology and Program in Molecular and Cellular Biology, University of Massachusetts, Amherst, Amherst, Massachusetts, USA
出版信息
mSphere. 2020 Mar 18;5(2):e00187-20. doi: 10.1128/mSphere.00187-20.
Simian virus 40 VP4 was discovered in 2007 as a later expressed viral protein initiated from a downstream Met on the VP2/VP3 transcript. VP4's role as a viroporin involved in viral release was supported in a series of additional articles that characterized the ability of VP4 to associate with and permeabilize biological membranes. This commentary is our response to the perspective from Henriksen and Rinaldo (mSphere 5:e00019-20, 2020, https://doi.org/10.1128/mSphere.00019-20) that challenges the existence of SV40 VP4.
2007 年发现了猿猴病毒 40 型 VP4，它是一种从 VP2/VP3 转录本的下游甲硫氨酸起始表达的晚期病毒蛋白。VP4 作为一种参与病毒释放的病毒孔蛋白的作用在一系列描述 VP4 与生物膜结合和渗透能力的额外文章中得到支持。这篇评论是我们对 Henriksen 和 Rinaldo 的观点（mSphere 5:e00019-20，2020，https://doi.org/10.1128/mSphere.00019-20）的回应，该观点质疑 SV40 VP4 的存在。
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