D-丝氨酸，形态变化的 NMDA 受体协同激动剂。
D-Serine, the Shape-Shifting NMDA Receptor Co-agonist.
机构信息
Department of Psychiatry, Harvard Medical School and McLean Hospital, Belmont, MA, 02478, USA.
Translational Psychiatry Laboratory, McLean Hospital, Belmont, MA, 02478, USA.
出版信息
Neurochem Res. 2020 Jun;45(6):1344-1353. doi: 10.1007/s11064-020-03014-1. Epub 2020 Mar 18.
Abstract
Shape-shifting, a phenomenon wide-spread in folklore, refers to the ability to physically change from one identity to another, typically from an innocuous entity to a destructive one. The amino acid D-serine over the last 25 years has "shape-shifted" into several identities: a purported glial transmitter activating N-methyl-D-aspartate receptors (NMDARs), a co-transmitter concentrated in excitatory glutamatergic neurons, an autocrine that is released at dendritic spines to prime their post-synaptic NMDARs for an instantaneous response to glutamate and an excitotoxic moiety released from inflammatory (A1) astrocytes. This article will review evidence in support of these scenarios and the artifacts that misled investigators of the true identity of D-serine.
摘要
变形，一种在民间传说中广泛存在的现象，是指身体从一种形态转变为另一种形态的能力，通常是从无害的实体转变为具有破坏性的实体。在过去的 25 年中，氨基酸 D-丝氨酸已经“变形”为几种身份：一种假定的神经胶质递质，激活 N-甲基-D-天冬氨酸受体（NMDARs）；一种集中在兴奋性谷氨酸能神经元中的共递质；一种自分泌物质，在树突棘中释放，使其突触后 NMDAR 对谷氨酸的即时反应和从炎症（A1）星形胶质细胞释放的兴奋毒性部分做好准备。本文将回顾支持这些情况的证据，以及误导 D-丝氨酸真实身份调查人员的假象。
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