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Follicular Dendritic Cell Sarcoma or Not? A Series of 5 Diagnostically Challenging Cases.是滤泡性树突状细胞肉瘤吗？5例诊断难题病例分析
Clin Med Insights Oncol. 2019 May 23;13:1179554919844531. doi: 10.1177/1179554919844531. eCollection 2019.
2
Primary Tonsillar Epithelioid Follicular Dendritic Cell Sarcoma: Report of a Rare Case Mimicking Undifferentiated Carcinoma and a Brief Review of the Literature.原发性扁桃体上皮样滤泡树突状细胞肉瘤：1例酷似未分化癌的罕见病例报告及文献复习
Head Neck Pathol. 2019 Dec;13(4):606-612. doi: 10.1007/s12105-019-01015-3. Epub 2019 Feb 13.
3
Human Papillomavirus Testing in Head and Neck Carcinomas: Guideline From the College of American Pathologists.人乳头瘤病毒检测在头颈部肿瘤中的应用：美国病理学家学院指南。
Arch Pathol Lab Med. 2018 May;142(5):559-597. doi: 10.5858/arpa.2017-0286-CP. Epub 2017 Dec 18.
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Follicular dendritic cell sarcoma of the head and neck. Literature review and report of the tonsil occurrence in a Ugandan patient.头颈部滤泡性树突状细胞肉瘤。文献综述及乌干达一名患者扁桃体发病情况报告
Pathologica. 2017 Jun;109(2):120-125.
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p16 expression in follicular dendritic cell sarcoma: a potential mimicker of human papillomavirus-related oropharyngeal squamous cell carcinoma.p16在滤泡性树突状细胞肉瘤中的表达：一种可能模仿人乳头瘤病毒相关口咽鳞状细胞癌的情况。
Hum Pathol. 2017 Aug;66:40-47. doi: 10.1016/j.humpath.2017.05.019. Epub 2017 May 26.
6
Clinicopathological Profile and Outcomes of Follicular Dendritic Cell Sarcoma of the Head and Neck Region - A Study of 10 Cases with Literature Review.头颈部滤泡性树突状细胞肉瘤的临床病理特征及预后——10例病例研究并文献复习
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Targeted genomic sequencing of follicular dendritic cell sarcoma reveals recurrent alterations in NF-κB regulatory genes.滤泡性树突状细胞肉瘤的靶向基因组测序揭示了NF-κB调控基因的复发性改变。
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扁桃体 p16 阳性滤泡树突状细胞肉瘤，模仿 HPV 相关口咽鳞状细胞癌：病例报告及文献复习。

Tonsillar p16-Positive Follicular Dendritic Cell Sarcoma Mimicking HPV-Related Oropharyngeal Squamous Cell Carcinoma: A Case Report and Review of Reported Cases.

机构信息

Department of Pathology, Massachusetts General Hospital, Boston, MA, USA.

Carolinas Pathology, Atrium Health Carolinas Medical Center, Charlotte, NC, USA.

出版信息

Head Neck Pathol. 2021 Mar;15(1):267-274. doi: 10.1007/s12105-020-01152-0. Epub 2020 Mar 18.

DOI:10.1007/s12105-020-01152-0
PMID:32189159
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8010052/
Abstract

Follicular dendritic cell sarcoma (FDCS) is a rare entity which can share morphologic features with non-keratinizing squamous cell carcinoma. Recent reports suggest that up to half of FDCSs show immunohistochemical positivity for p16 (Zhang et al., in Hum Pathol 66:40-47, 2017), a stain that is conventionally used in the risk stratification of oropharyngeal squamous cell carcinoma (OPSCC). Herein, we report a case of p16-positive FDCS with clinical and histomorphologic overlap with human papilloma virus (HPV)-related OPSCC.

摘要

滤泡树突状细胞肉瘤（FDCS）是一种罕见的实体瘤，其形态学特征可与非角化性鳞状细胞癌相似。最近的报告表明，多达一半的 FDCS 表现为 p16 免疫组织化学阳性（Zhang 等人，发表于《Hum Pathol》66:40-47, 2017），p16 是一种常用于口咽鳞状细胞癌（OPSCC）风险分层的染色剂。在此，我们报告一例 p16 阳性 FDCS，其临床表现和组织形态学与 HPV 相关的 OPSCC 重叠。