扁桃体 p16 阳性滤泡树突状细胞肉瘤，模仿 HPV 相关口咽鳞状细胞癌：病例报告及文献复习。
Tonsillar p16-Positive Follicular Dendritic Cell Sarcoma Mimicking HPV-Related Oropharyngeal Squamous Cell Carcinoma: A Case Report and Review of Reported Cases.
机构信息
Department of Pathology, Massachusetts General Hospital, Boston, MA, USA.
Carolinas Pathology, Atrium Health Carolinas Medical Center, Charlotte, NC, USA.
出版信息
Head Neck Pathol. 2021 Mar;15(1):267-274. doi: 10.1007/s12105-020-01152-0. Epub 2020 Mar 18.
Abstract
Follicular dendritic cell sarcoma (FDCS) is a rare entity which can share morphologic features with non-keratinizing squamous cell carcinoma. Recent reports suggest that up to half of FDCSs show immunohistochemical positivity for p16 (Zhang et al., in Hum Pathol 66:40-47, 2017), a stain that is conventionally used in the risk stratification of oropharyngeal squamous cell carcinoma (OPSCC). Herein, we report a case of p16-positive FDCS with clinical and histomorphologic overlap with human papilloma virus (HPV)-related OPSCC.
摘要
滤泡树突状细胞肉瘤（FDCS）是一种罕见的实体瘤，其形态学特征可与非角化性鳞状细胞癌相似。最近的报告表明，多达一半的 FDCS 表现为 p16 免疫组织化学阳性（Zhang 等人，发表于《Hum Pathol》66:40-47, 2017），p16 是一种常用于口咽鳞状细胞癌（OPSCC）风险分层的染色剂。在此，我们报告一例 p16 阳性 FDCS，其临床表现和组织形态学与 HPV 相关的 OPSCC 重叠。
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