QIMR Berghofer Medical Research Institute, Herston, Australia.
Liverpool School of Tropical Medicine, Liverpool, United Kingdom.
Am J Trop Med Hyg. 2020 May;102(5):934-939. doi: 10.4269/ajtmh.19-0351.
Malaria clinical studies entailing the experimental infection of healthy volunteers with parasites by bites from infected mosquitos, injection of cryopreserved sporozoites, or injection of blood-stage parasites provide valuable information for vaccine and drug development. Success of these studies depends on maintaining safety. In this mini-review, we discuss the safety risks and associated mitigation strategies of these three types of experimental malaria infection. We aimed to inform researchers and regulators who are currently involved in or are planning to establish experimental malaria infection studies in endemic or non-endemic settings.
疟疾临床研究包括通过受感染蚊子叮咬、注射冷冻保存的疟原虫孢子或注射血液期寄生虫使健康志愿者感染寄生虫，为疫苗和药物开发提供了有价值的信息。这些研究的成功取决于安全性的维护。在这篇迷你综述中，我们讨论了这三种类型的实验性疟疾感染的安全风险及相关缓解策略。我们旨在为目前参与或计划在流行地区或非流行地区建立实验性疟疾感染研究的研究人员和监管机构提供信息。
