氨氯地平在动物肿瘤模型中的抗转移作用。
Antimetastatic effect of amiloride in an animal tumour model.
作者信息
Kellen J A, Mirakian A, Kolin A
机构信息
Department of Clinical Biochemistry, Sunnybrook Medical Centre, University of Toronto, Ontario, Canada.
出版信息
Anticancer Res. 1988 Nov-Dec;8(6):1373-6.
PMID:3218971
Abstract
The diuretic Amiloride competitively inhibits the catalytic activity of the urokinase-type plasminogen activator on plasminogen in vitro. This effect was tested on a rat adenocarcinoma model and its invasive potential in the host lung. While the inhibitory effect on intact cell cultures of the tumour was slight, continuous exposure of tumour-injected animals to the drug completely prevented the formation of lung metastasis.
摘要
利尿剂阿米洛利在体外可竞争性抑制尿激酶型纤溶酶原激活剂对纤溶酶原的催化活性。在大鼠腺癌模型及其在宿主肺中的侵袭潜力上对该效应进行了测试。虽然对肿瘤完整细胞培养物的抑制作用轻微，但给注射肿瘤的动物持续使用该药物可完全阻止肺转移的形成。
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