一种合成DL-4-羟基-3-甲氧基扁桃酸（DL-“香草基”-扁桃酸，VMA）的改进方法。
An Improved Procedure for Synthesis of DL-4-Hydroxy-3-methoxymandelic Acid (DL-"Vanillyl"-mandelic Acid, VMA).
作者信息
Fatiadi Alexander J, Schaffer Robert
机构信息
Institute for Materials Research, National Bureau of Standards, Washington, D.C. 20234.
出版信息
J Res Natl Bur Stand A Phys Chem. 1974 May-Jun;78A(3):411-412. doi: 10.6028/jres.078A.024.
Abstract
An improved procedure for synthesis of DL-4-Hydroxy-3-methoxymandelic Acid (DL-Vanillyl-mandelic Acid, VMA) entails slow addition of an ice-cold, aqueous solution of glyoxylic acid to an ice-cold alkaline solution of guaiacol, with efficient mechanical stirring. This one-step condensation procedure provides VMA in 68-75 percent yield.
摘要
一种改进的合成DL-4-羟基-3-甲氧基扁桃酸（DL-香草扁桃酸，VMA）的方法，是在高效机械搅拌下，将冰冷的乙醛酸水溶液缓慢加入到冰冷的愈创木酚碱性溶液中。这一步缩合反应可使VMA的产率达到68%-75%。
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An Improved Procedure for Synthesis of DL-4-Hydroxy-3-methoxymandelic Acid (DL-"Vanillyl"-mandelic Acid, VMA).一种合成DL-4-羟基-3-甲氧基扁桃酸（DL-“香草基”-扁桃酸，VMA）的改进方法。
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