铅通过母亲身体进入孩子体内的途径。
The pathway of lead through the mother's body to the child.
作者信息
RÍsovÁ Vanda
机构信息
Institute of Histology and Embryology, Faculty of Medicine, Comenius University, Bratislava, Slovakia.
出版信息
Interdiscip Toxicol. 2019 Sep;12(1):1-6. doi: 10.2478/intox-2019-0001. Epub 2020 Feb 20.
Abstract
Placenta, the organ on which great attention is concentrated during pregnancy, represents an ineffective barrier to the transfer of hazardous heavy metals, mainly lead, into the foetus. The presence of lead in the placenta is an environmental hazard for a person's future. Due to hormonal changes, lead is released during pregnancy into the bloodstream of the mother from deposits in the bones and in the teeth, where it has accumulated for years as a result of a contaminated environment. Since lead is a neurotoxic metal, exposure to lead during prenatal and postnatal development can cause serious neurocognitive damage and hence the development of an Attention Deficit Hyperactivity Disorder (ADHD) in a developing human. Our work provides an overall picture of the "toxic pathway" of lead through the mother's body, the risks arising from its transplacental transfer and its accumulation in the developing foetus as well as effective prevention to protect all newborns.
摘要
胎盘是孕期备受关注的器官，它对有害重金属（主要是铅）向胎儿的转移而言是一道无效屏障。胎盘中铅的存在对一个人的未来构成环境危害。由于激素变化，孕期铅会从骨骼和牙齿中的沉积物释放到母亲的血液中，这些铅因环境污染已在骨骼和牙齿中积累多年。由于铅是一种神经毒性金属，产前和产后发育期间接触铅会导致严重的神经认知损伤，进而使发育中的人类患上注意力缺陷多动障碍（ADHD）。我们的工作全面呈现了铅在母亲体内的“毒性路径”、经胎盘转移所产生的风险及其在发育中胎儿体内的蓄积情况，以及保护所有新生儿的有效预防措施。
相似文献
1
The pathway of lead through the mother's body to the child.
Interdiscip Toxicol. 2019 Sep;12(1):1-6. doi: 10.2478/intox-2019-0001. Epub 2020 Feb 20.
2
Placenta and umbilical cord blood deserve attention.
Neuro Endocrinol Lett. 2010;31(1):47-55.
3
Occurrence of lead in placenta--important information for prenatal and postnatal development of child.
Neuro Endocrinol Lett. 2007 Aug;28(4):335-40.
4
S100β in heavy metal-related child attention-deficit hyperactivity disorder in an informal e-waste recycling area.
Neurotoxicology. 2014 Dec;45:185-91. doi: 10.1016/j.neuro.2014.10.013. Epub 2014 Nov 1.
5
Metal and essential element concentrations during pregnancy and associations with autism spectrum disorder and attention-deficit/hyperactivity disorder in children.
Environ Int. 2021 Jul;152:106468. doi: 10.1016/j.envint.2021.106468. Epub 2021 Mar 22.
6
[Potential interaction effect on attention-deficit/hyperactivity disorder between mother's educational level and preschoolers' dietary pattern].
Zhonghua Liu Xing Bing Xue Za Zhi. 2018 Apr 10;39(4):464-468. doi: 10.3760/cma.j.issn.0254-6450.2018.04.015.
7
Lead, mercury, and cadmium exposure and attention deficit hyperactivity disorder in children.
Environ Res. 2013 Oct;126:105-10. doi: 10.1016/j.envres.2013.08.008. Epub 2013 Sep 10.
8
Environmental exposure to lead, but not other neurotoxic metals, relates to core elements of ADHD in Romanian children: performance and questionnaire data.
Environ Res. 2010 Jul;110(5):476-83. doi: 10.1016/j.envres.2010.04.002.
9
Predicting attention deficit hyperactivity disorder using pregnancy and birth characteristics.
Arch Gynecol Obstet. 2018 Nov;298(5):889-895. doi: 10.1007/s00404-018-4888-0. Epub 2018 Sep 8.
10
Prenatal exposure to dental amalgam and risk of symptoms of attention-deficit and hyperactivity disorder (ADHD).
Community Dent Oral Epidemiol. 2018 Oct;46(5):472-481. doi: 10.1111/cdoe.12409. Epub 2018 Aug 7.
引用本文的文献
1
Africa, an Emerging Exporter of Turmeric: Combating Fraud with Rapid Detection Systems.
Foods. 2025 Apr 30;14(9):1590. doi: 10.3390/foods14091590.
2
Prevalence of Exposure to Environmental Metal Mixtures Among Pregnant Women in the United States National Health and Nutrition Examination Survey (NHANES) 1999-2018.
J Xenobiot. 2025 Mar 1;15(2):38. doi: 10.3390/jox15020038.
3
Sex dependent intergenerational effects of lead in mouse model.
Sci Rep. 2024 Dec 4;14(1):30233. doi: 10.1038/s41598-024-81839-4.
4
Lead and arsenic intoxications by traditional and alternative medicine: men are more sensitive than women.
Naunyn Schmiedebergs Arch Pharmacol. 2025 Jan;398(1):799-818. doi: 10.1007/s00210-024-03317-y. Epub 2024 Jul 27.
5
Metal Levels in Striped Dolphins () and Common Dolphins () Stranded along the Sicilian Coastlines of the Mediterranean Sea.
Animals (Basel). 2024 Jul 14;14(14):2063. doi: 10.3390/ani14142063.
6
Trace metals concentrations in fresh milk from dairy farms and stores: An assessment of human health risk.
Toxicol Rep. 2024 Mar 20;12:361-368. doi: 10.1016/j.toxrep.2024.03.007. eCollection 2024 Jun.
7
Blood lead levels in pregnant women and their newborn infants at an Indian teaching hospital.
J Family Med Prim Care. 2024 Jan;13(1):348-355. doi: 10.4103/jfmpc.jfmpc_963_23. Epub 2024 Feb 8.
8
Isotopic analysis of formula milk reveals potential challenges in geolocating bottle-fed babies.
Sci Rep. 2024 Feb 13;14(1):3600. doi: 10.1038/s41598-024-54173-y.
9
Relationship between lead concentration in maternal and umbilical cord blood and some neonatal outcomes in primiparous opium-dependent mothers in Zahedan, Southeast of Iran in 2022.
BMC Pregnancy Childbirth. 2023 Oct 25;23(1):753. doi: 10.1186/s12884-023-06068-5.
10
Correlations Among Maternal and Infant Factors, Lead Exposure, and Serum Prolactin Levels During Lactation: A Cross-sectional Study in Indonesia.
J Prev Med Public Health. 2023 Sep;56(5):422-430. doi: 10.3961/jpmph.23.238. Epub 2023 Aug 22.
本文引用的文献
1
The genetic and environmental contributions to attention deficit hyperactivity disorder as measured by the Conners' Rating Scales--Revised.
Am J Psychiatry. 2005 Sep;162(9):1614-20. doi: 10.1176/appi.ajp.162.9.1614.
2
Genetic influences on the stability of attention-deficit/hyperactivity disorder symptoms from early to middle childhood.
Biol Psychiatry. 2005 Mar 15;57(6):647-54. doi: 10.1016/j.biopsych.2004.12.032.
3
Calcium channels, transporters and exchangers in placenta: a review.
Cell Calcium. 2005 Jan;37(1):1-8. doi: 10.1016/j.ceca.2004.06.010.
4
Low environmental contamination by lead in pregnant women: effect on calcium transfer in human placental syncytiotrophoblasts.
J Toxicol Environ Health A. 2004 Jul 23;67(14):1069-79. doi: 10.1080/15287390490452263.
5
Recent developments in low-level lead exposure and intellectual impairment in children.
Environ Health Perspect. 2004 Jun;112(9):987-94. doi: 10.1289/ehp.6941.
6
Prevalence of blood lead levels >or= 5 micro g/dL among US children 1 to 5 years of age and socioeconomic and demographic factors associated with blood of lead levels 5 to 10 micro g/dL, Third National Health and Nutrition Examination Survey, 1988-1994.
Pediatrics. 2003 Dec;112(6 Pt 1):1308-13. doi: 10.1542/peds.112.6.1308.
7
The isoform- and location-dependence of the functioning of the plasma membrane calcium pump.
Cell Mol Biol Lett. 2002;7(4):1037-45.
8
Effects of metals on the nervous system of humans and animals.
Int J Occup Med Environ Health. 2001;14(3):209-18.
9
Lead as a carcinogen: experimental evidence and mechanisms of action.
Am J Ind Med. 2000 Sep;38(3):316-23. doi: 10.1002/1097-0274(200009)38:3<316::aid-ajim11>3.0.co;2-p.
10
Third-trimester amniotic fluid metal levels associated with preeclampsia.
Arch Environ Health. 1999 Nov-Dec;54(6):412-5. doi: 10.1080/00039899909603372.
Zotero 插件