Mathew Boon, Purandare Nilendu C, Puranik Ameya, Shah Sneha, Agrawal Archi, Pramesh C S, Karimundackal George, Jiwnani Sabita, Rangarajan Venkatesh
Department of Nuclear Medicine and Molecular Imaging, Tata Memorial Hospital, Homi Bhabha National Institute, Mumbai, Maharashtra, India.
Department of Surgical Oncology, Tata Memorial Hospital, Homi Bhabha National Institute, Mumbai, Maharashtra, India.
World J Nucl Med. 2020 Feb 27;19(1):8-14. doi: 10.4103/wjnm.WJNM_26_19. eCollection 2020 Jan-Mar.
F-fluorodeoxyglucose positron emission tomography-computed tomography-derived metabolic parameters can play a role in prognostication. We investigated the prognostic value of various metabolic parameters such as maximum standardized uptake value (SUV), mean SUV (SUV), whole-body metabolic tumor volume (WBMTV), and whole-body total lesion glycolysis (WBTLG) in surgically resected non-small cell lung cancer (NSCLC) patients. We retrospectively reviewed 153 patients with NSCLC who underwent surgical resection. The SUV, SUV, WBMTV, and WBTLG of the tumor were measured. Continuous PET parameters were stratified by receiver operating characteristic curve analysis. Prognostic factors were estimated using the Kaplan-Meier method and Cox proportional hazards model. The median follow-up was 36.9 months. Fifty-six patients died and 78 patients had recurrence. On univariate analysis, tumor-node-metastasis (TNM) stage; male sex; no adjuvant treatment; and higher SUV, SUV, WBMTV, and WBTLG were statistically significant and were associated with poor overall survival (OS). TNM stage; no adjuvant treatment; and higher SUV, SUV mean, WBMTV, and WBTLG were statistically significant and were associated with poor disease-free survival (DFS). On multivariate analysis, higher WBTLG (hazard ratio [HR] = 3.08, = 0.007) for DFS and higher WBTLG (HR = 2.70, = 0.041) and TNM staging (HR = 1.63, = 0.035) for OS were statistically significant. Whole-body tumor burden assessment with TLG has independent prognostic value in patients with operated lung cancer. Incorporation of TLG into clinical practice can identify patients benefitted from additional therapy.
氟脱氧葡萄糖正电子发射断层扫描-计算机断层扫描得出的代谢参数可在预后评估中发挥作用。我们研究了各种代谢参数，如最大标准化摄取值（SUV）、平均SUV（SUV）、全身代谢肿瘤体积（WBMTV）和全身总病灶糖酵解（WBTLG）在接受手术切除的非小细胞肺癌（NSCLC）患者中的预后价值。我们回顾性分析了153例接受手术切除的NSCLC患者。测量了肿瘤的SUV、SUV、WBMTV和WBTLG。通过受试者工作特征曲线分析对连续的PET参数进行分层。使用Kaplan-Meier法和Cox比例风险模型评估预后因素。中位随访时间为36.9个月。56例患者死亡，78例患者复发。单因素分析显示，肿瘤-淋巴结-转移（TNM）分期、男性、未接受辅助治疗以及较高的SUV、SUV、WBMTV和WBTLG具有统计学意义，且与总生存期（OS）较差相关。TNM分期、未接受辅助治疗以及较高的SUV、平均SUV、WBMTV和WBTLG具有统计学意义，且与无病生存期（DFS）较差相关。多因素分析显示，较高的WBTLG（风险比[HR]=3.08，P=0.007）对DFS有统计学意义，较高的WBTLG（HR=2.70，P=0.041）和TNM分期（HR=1.63,P=0.035）对OS有统计学意义。用TLG进行全身肿瘤负荷评估对接受手术的肺癌患者具有独立的预后价值。将TLG纳入临床实践可以识别出可能从额外治疗中获益的患者。
