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添加浓缩乳清蛋白和硫酸锌的合生元豆浆对胆管结扎诱导的肝性脑病的保护作用。

Protective effects of synbiotic soymilk fortified with whey protein concentrate and zinc sulfate against bile duct ligated-induced hepatic encephalopathy.

作者信息

Jalilpiran Yahya, Tanideh Nader, Rahmdel Samane, Azarpira Negar, Mokhtari Maral, Mazloom Zohreh

机构信息

Department of Clinical Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.

Students' Scientific Research Center (SSRC), Tehran University of Medical Sciences (TUMS), Tehran, Iran.

出版信息

Gastroenterol Hepatol Bed Bench. 2020 Winter;13(1):64-76.

PMID:32190227
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7069541/
Abstract

AIM

This study aimed to compare the effects of synbiotic soymilk fortified with whey protein concentrate and zinc sulfate with lactulose on bile duct ligated-induced HE.

BACKGROUND

Hepatic encephalopathy (HE) is seriously associated with neuromuscular and cognitive alterations.

METHODS

Eighty-two Sprague Dawley rats were randomly assigned into seven groups (sham, bile duct ligation (BDL), BDL + lactulose, BDL + soymilk (SM), BDL + Synbiotic soymilk (SSM), BDL + SSM + whey protein concentrate (WPC), BDL + SSM + WPC + ZnSO4). Different SM products, lactulose, and normal saline were administered via oral gavage (2 mL/rat/day). The serum and liver markers as well as liver histopathology were assessed after 28 days.

RESULTS

The SM products significantly reduced the serum alanine aminotransferase, albumin, and ammonia ( < 0.05). The levels of aspartate aminotransferase, endotoxin, and liver interleukin-6 improved significantly in all treatments, except for those receiving SM. SSM and SSM + WPC + ZnSO4 were the only effective products in reducing serum alkaline phosphatase ( < 0.05). Furthermore, the liver total antioxidant capacity was greater (<0.05) in the SSM + WPC and SSM + WPC + ZnSO4 groups. The histopathological examinations confirmed the efficiency of all SM products in reducing liver fibrosis. Liver bile duct proliferation diminished only in the SSM + WPC and SSM + WPC+ ZnSO4 groups (P<0.05).

CONCLUSION

This study showed the positive effects of different SM products, especially SSM + WPC and SSM + WPC + ZnSO4, on HE. Further studies are required to confirm our findings.

摘要

目的

本研究旨在比较添加浓缩乳清蛋白和硫酸锌的合生元豆浆与乳果糖对胆管结扎诱导的肝性脑病（HE）的影响。

背景

肝性脑病（HE）与神经肌肉和认知改变密切相关。

方法

将82只Sprague Dawley大鼠随机分为七组（假手术组、胆管结扎组（BDL）、BDL + 乳果糖组、BDL + 豆浆组（SM）、BDL + 合生元豆浆组（SSM）、BDL + SSM + 浓缩乳清蛋白组（WPC）、BDL + SSM + WPC + 硫酸锌组）。通过灌胃给予不同的豆浆产品、乳果糖和生理盐水（2 mL/大鼠/天）。28天后评估血清和肝脏标志物以及肝脏组织病理学。

结果

豆浆产品显著降低了血清丙氨酸转氨酶、白蛋白和氨水平（P<0.05）。除接受豆浆的组外，所有治疗组的天冬氨酸转氨酶、内毒素和肝脏白细胞介素-6水平均显著改善。SSM和SSM + WPC + 硫酸锌是仅有的能有效降低血清碱性磷酸酶的产品（P<0.05）。此外，SSM + WPC组和SSM + WPC + 硫酸锌组的肝脏总抗氧化能力更强（P<0.05）。组织病理学检查证实所有豆浆产品在减轻肝纤维化方面均有效。仅SSM + WPC组和SSM + WPC + 硫酸锌组的肝脏胆管增生减少（P<0.05）。

结论

本研究表明不同的豆浆产品，尤其是SSM + WPC和SSM + WPC + 硫酸锌，对肝性脑病有积极作用。需要进一步研究来证实我们的发现。

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