Yang Lei, Qin Wei, Li Yue, Yang Shuna, Gu Hua, Hu Wenli
Department of Neurology, Beijing Chaoyang Hospital, Capital Medical University, No. 8, South Gongti Road, Beijing 100020, China.
Department of Radiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing China.
Open Med (Wars). 2020 Mar 8;15:160-166. doi: 10.1515/med-2020-0025. eCollection 2020.
We hypothesized that the current criteria may be unsuitable for lacunar pontine infarctions (LPI) diagnosis and that size criteria may indicate different stroke mechanisms.
A total of 102 patients with isolated pontine infarctions were divided into a parent artery disease (PAD) and non-PAD groups according to stenosis of basilar artery. Further, 86 patients from the non-PAD group were divided into paramedian pontine infarction (PPI) and LPI groups. Data were collected from the three groups. The "golden" criterion for LPI was established based on the location of the infarction. A receiver operating characteristic (ROC) curve were used to evaluate the optimal cutoff value to use as an LPI diagnostic indicator.
There was a high prevalence of patients with PAD in both asymptomatic carotid atherosclerosis (ACAS) and PPI groups. Patients with PPI had a higher prevalence in diabetes and ACAS than those with LPI. Based upon the ROC curve, the optimal lesion size cutoff value for use as an LPI diagnostic indicator was 11.8 mm.
Diffusion weighted imaging (DWI) cutoff points for predicting LPI may differ from that of the middle cerebral artery territory. The diameter of LPI may also indicate different stroke mechanisms.
我们推测当前的标准可能不适用于腔隙性脑桥梗死（LPI）的诊断，且大小标准可能提示不同的卒中机制。
总共102例孤立性脑桥梗死患者根据基底动脉狭窄情况被分为主干动脉疾病（PAD）组和非PAD组。此外，非PAD组中的86例患者被分为脑桥旁正中梗死（PPI）组和LPI组。收集三组的数据。基于梗死部位建立LPI的“金标准”。使用受试者工作特征（ROC）曲线评估用作LPI诊断指标的最佳截断值。
无症状性颈动脉粥样硬化（ACAS）组和PPI组中PAD患者的患病率都很高。PPI患者中糖尿病和ACAS的患病率高于LPI患者。根据ROC曲线，用作LPI诊断指标的最佳病变大小截断值为11.8毫米。
预测LPI的扩散加权成像（DWI）截断点可能与大脑中动脉区域的截断点不同。LPI的直径也可能提示不同的卒中机制。
