多中心儿科克罗恩病生长研究介绍及筛查访视结果。

Introduction to and Screening Visit Results of the Multicenter Pediatric Crohn's Disease Growth Study.

机构信息

Department of Pediatrics, Weill Cornell Medicine, New York, NY.

Division of Endocrinology, Department of Pediatrics, University of California, San Francisco, San Francisco, CA.

出版信息

Inflamm Bowel Dis. 2020 Nov 19;26(12):1945-1950. doi: 10.1093/ibd/izaa023.

DOI:10.1093/ibd/izaa023

PMID:32190893

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7676423/

Abstract

BACKGROUND

Statural growth impairment is more common in males with Crohn's disease (CD). We assessed sex differences in height Z score differences and bone age (BA) Z scores and characterized age of menarche in a novel contemporary cohort of pediatric CD patients undergoing screening for enrollment in the multicenter longitudinal Growth Study.

METHODS

Crohn's disease patients (females with chronological age [CA] 5 years and older and younger than 14 years; males with CA 6 years and older and younger than 16 years) participated in a screening visit for the Growth Study. Height BA-Z scores are height Z scores calculated based on BA. Height CA-Z scores are height Z scores calculated based on CA. The height Z score difference equals height CA-Z score minus height BA-Z score.

RESULTS

One hundred seventy-one patients (60% male) qualified for this analysis. Mean CA was 12.2 years. Mean height CA-Z score was -0.4, and mean height BA-Z score was 0.4 in females. Mean height CA-Z score was -0.1, and mean height BA-Z score was 0.2 in males. The absolute value of the mean height Z score difference was significantly greater in females (0.8) than males (0.3; P = 0.005). The mean BA-Z score in females (-1.0) was significantly lower than in males (-0.2; P = 0.002). The median CA at menarche was 13.6 (95% CI, 12.6-14.6) years.

CONCLUSIONS

Our screening visit data suggest that standardized height gain is lower in males with skeletal maturation and delayed puberty is common in females in CD. We are investigating these findings in the ongoing Growth Study.

摘要

背景

克罗恩病（CD）患者中，男性的身高生长受损更为常见。我们评估了身高 Z 评分差异和骨龄（BA）Z 评分的性别差异，并对接受筛查以入组多中心纵向生长研究的新的儿科 CD 患者群体中的初潮年龄进行了特征描述。

方法

CD 患者（女性，年龄为 5 岁及以上且小于 14 岁；男性，年龄为 6 岁及以上且小于 16 岁）参加了生长研究的筛查就诊。BA-Z 评分是基于 BA 计算的身高 Z 评分。CA-Z 评分是基于 CA 计算的身高 Z 评分。身高 Z 评分差异等于 CA-Z 评分减去 BA-Z 评分。

结果

171 名患者（60%为男性）符合本分析条件。平均 CA 为 12.2 岁。女性的平均 CA-Z 评分是-0.4，平均 BA-Z 评分是 0.4。男性的平均 CA-Z 评分是-0.1，平均 BA-Z 评分是 0.2。女性的身高 Z 评分差异绝对值（0.8）显著大于男性（0.3；P=0.005）。女性的 BA-Z 评分（-1.0）显著低于男性（-0.2；P=0.002）。初潮的中位 CA 为 13.6（95%CI，12.6-14.6）岁。