Department of Ophthalmology, Zhongshan Hospital, Fudan University, 180# Fenglin Road, 200032, Shanghai, China.
Cell Biol Int. 2020 Jul;44(7):1416-1425. doi: 10.1002/cbin.11345. Epub 2020 Mar 27.
Nuclear-cytoplasmic transport is necessary for the biological function of nuclear proteins. The mechanism underlying this process is very complex and has been a subject of intense research. Yes-associated protein (YAP), a Hippo signaling pathway effector, localizes to both the cytoplasm and the nucleus and can influence cell proliferation, stem cell status, and tissue homeostasis. Recent studies have focused on the significance of YAP distribution between the nucleus and the cytoplasm in disease, but it remains unclear how this dynamic process is regulated. In this review, we discuss YAP nuclear-cytoplasmic transport under different physiological and pathological conditions in terms of mechanical signaling, protein modification, and metabolism. Understanding the mechanisms underlying nuclear-cytoplasmic YAP transport mechanism under different physiological and pathological conditions may help identify important targets for disease treatment.
核质转运对于核蛋白的生物学功能是必需的。这个过程的机制非常复杂，一直是研究的热点。Yes 相关蛋白（YAP）是 Hippo 信号通路的效应物，定位于细胞质和细胞核，能够影响细胞增殖、干细胞状态和组织稳态。最近的研究集中在 YAP 在细胞核和细胞质之间的分布在疾病中的意义，但尚不清楚这个动态过程是如何被调节的。在这篇综述中，我们讨论了 YAP 在不同生理和病理条件下的核质转运的机械信号、蛋白质修饰和代谢。了解不同生理和病理条件下核质 YAP 转运机制的机制可能有助于确定疾病治疗的重要靶点。
