Rheumatology Unit, Internal Medicine Department, Al Adan Hospital, Al Ahmadi, Kuwait.
Rheumatology Department, Faculty of Medicine, Benha University, Benha, Egypt.
Lupus. 2020 Jun;29(7):791-794. doi: 10.1177/0961203320913944. Epub 2020 Mar 19.
Lupus erythematosus profundus (LEP) is an unusual form of cutaneous lupus erythematosus (CLE) characterized by multiple subcutaneous induration and associated with considerable physical and psychological morbidity. The heterogeneity of CLE makes it difficult to understand its underlying pathogenesis and represents a therapeutic challenge. Recently, new insight into the pathogenesis of CLE has implicated various cytokines, opening doors to targeted biologic agents. We report a case of a 23-year-old female who presented with refractory LEP ulcers as an initial presentation of systemic lupus erythematosus. The lesions were resistant to multiple conventional therapies and remarkably responded to tocilizumab.
深部红斑狼疮（LEP）是一种不常见的皮肤红斑狼疮（CLE）形式，其特征为多个皮下硬结，并伴有相当大的身体和心理发病率。CLE 的异质性使其难以理解其潜在的发病机制，并代表了治疗上的挑战。最近，对 CLE 发病机制的新认识表明了各种细胞因子的作用，为靶向生物制剂开辟了道路。我们报告了一例 23 岁女性，以系统性红斑狼疮的首发表现为难治性 LEP 溃疡。这些病变对多种常规治疗方法均有耐药性，而托珠单抗治疗效果显著。
