Torem S, Schneider P A, Paxton L D, Yasuda H, Hanson S R
Department of Surgery, Scripps Clinic and Research Foundation, La Jolla, CA 92037.
ASAIO Trans. 1988 Oct-Dec;34(4):916-20.
Scintillation camera imaging of 111Indium-labeled platelets has been used to measure acute thrombus formation on modified expanded Teflon (ePTFE) vascular grafts (Gore-Tex, 4.0 mm i.d. x 3-5 cm in length, W. L. Gore and Associates, Inc., Flagstaff, AZ) placed in the carotid arteries of normal baboons. Platelet deposition plateaued over 2 hr postoperatively and occurred primarily at the graft-vessel anastomoses. A positive correlation was found between the circulating platelet count in individual animals and the extent of early platelet thrombus deposition. Unmodified ePTFE grafts accumulated 4.6 +/- 1.2 x 10(9) platelets per graft, or 2.3 +/- 0.71 x 10(9) platelets per anastomosis. Acutely, platelet accumulation was reduced versus control graft results by coating the graft lumenal surfaces with a smooth layer of silicone rubber polymer (0.60 +/- 0.19 x 10(9) platelets per anastomosis; P less than 0.02) but not by coating the grafts using a plasma polymer based on methane, which did not modify graft texture (8.2 +/- 1.7 x 10(9) platelets per graft; P greater than 0.10). The benefit of the silicone rubber coating persisted for at least 48 hr. However, longer term patency was not preserved because 10 of 12 grafts placed had failed within 1 to 2 months.
用闪烁照相机对铟-111标记的血小板进行成像，已被用于测量置于正常狒狒颈动脉的改性膨体聚四氟乙烯（ePTFE）血管移植物（戈尔-tex，内径4.0毫米，长3 - 5厘米，W.L.戈尔联合公司，亚利桑那州弗拉格斯塔夫）上的急性血栓形成情况。血小板沉积在术后2小时达到平台期，主要发生在移植物与血管的吻合处。发现个体动物的循环血小板计数与早期血小板血栓沉积程度之间呈正相关。未改性的ePTFE移植物每个移植物积累4.6±1.2×10⁹个血小板，或每个吻合处积累2.3±0.71×10⁹个血小板。急性情况下，通过在移植物管腔表面涂覆一层光滑的硅橡胶聚合物，血小板积累相对于对照移植物结果有所减少（每个吻合处0.60±0.19×10⁹个血小板；P＜0.02），但用基于甲烷的等离子体聚合物涂覆移植物（未改变移植物质地）则没有这种效果（每个移植物8.2±1.7×10⁹个血小板；P＞0.10）。硅橡胶涂层的益处至少持续48小时。然而，长期通畅性并未得到维持，因为所植入的12个移植物中有10个在1至2个月内失效。
