Hypertension Unit, Department of Medicine, DIMED, University of Padova, Padova, Italy.
Hypertension Unit, Department of Medicine, DIMED, University of Padova, Padova, Italy.
Ann Endocrinol (Paris). 2021 Jun;82(3-4):174-178. doi: 10.1016/j.ando.2020.02.006. Epub 2020 Feb 28.
Primary aldosteronism (PA), the most common form of secondary hypertension, has been considered for decades as a "benign" form of hypertension, but evidences progressively built up to show that patients with PA had an excess rate of cardiovascular damage as compared to blood pressure-matched essential hypertensive patients. This review provides an updated view of structural and electrical cardiac remodeling and of vascular changes in hyperaldosteronism, and how they can favor development of cardiovascular events. The link between hyperaldosteronism and resistant hypertension is also examined, and the impact of targeted treatment of hyperaldosteronism on cardiovascular changes is finally discussed.
原发性醛固酮增多症（PA）是最常见的继发性高血压形式，几十年来一直被认为是一种“良性”高血压形式，但越来越多的证据表明，与血压匹配的原发性高血压患者相比，PA 患者的心血管损害发生率更高。本文综述了醛固酮增多症中心脏结构和电重构以及血管变化的最新观点，以及它们如何促进心血管事件的发生。还检查了醛固酮增多症与难治性高血压之间的联系，并最后讨论了针对醛固酮增多症的靶向治疗对心血管变化的影响。
