Nagano Nahoko, Ishikawa Noriyoshi, Nagase Mamiko, Araki Asuka, Iwahashi Teruaki, Maruyama Riruke
Department of Surgical Pathology, Shimane University Hospital, Japan.
Department of Surgical Pathology, Shimane University Hospital, Japan.
Int J Surg Case Rep. 2020;68:228-233. doi: 10.1016/j.ijscr.2020.03.012. Epub 2020 Mar 7.
Sclerosing epithelioid sarcoma (SEF) is a rare fibroblastic sarcoma. It is classically composed of cords of epithelioid cells embedded in a hyalinized stroma; however, cases of cellular variants also exist. A cellular variants of SEF can mimic Plasmacytoma/Myeloma (PM) and myoepithelioma. Hence, accurate diagnosis of SEF is important for cytologists and pathologists.
We present the case of a 75-year-old female patient diagnosed with a cellular variant of SEF occurring in the erector spinal muscle. Immunostaining of MUC4 and fluorescence in situ hybridization of EWSR1 (break-apart signal) were used for diagnosis.
The cellular variants of SEF presented diagnostic difficulties in fine needle aspiration. Moreover, it could not be distinguished from PM.
硬化性上皮样肉瘤（SEF）是一种罕见的纤维母细胞肉瘤。其典型特征是由嵌入透明化基质中的上皮样细胞索组成；然而，也存在细胞变异型病例。SEF的细胞变异型可模仿浆细胞瘤/骨髓瘤（PM）和肌上皮瘤。因此，准确诊断SEF对细胞学家和病理学家而言至关重要。
我们报告一例75岁女性患者，其诊断为发生于竖脊肌的SEF细胞变异型。采用MUC4免疫染色和EWSR1荧光原位杂交（断裂信号）进行诊断。
SEF的细胞变异型在细针穿刺抽吸中存在诊断困难。此外，它无法与PM区分开来。
