Department of Biochemistry and Molecular Biology, University of California-Riverside, Riverside, CA 92521, USA.
Chem Commun (Camb). 2020 Apr 21;56(31):4352-4355. doi: 10.1039/d0cc01489c. Epub 2020 Mar 20.
A water-soluble host molecule can bind tetrahydrocannabinol (Δ-THC) and its metabolites in aqueous solution. By pairing this recognition event in a sensing array with fluorescent reporters and varying external mediators, pattern recognition-based detection is possible, which allows selective discrimination of the THC metabolites. The selective sensing can be performed in aqueous solution with micromolar sensitivity, as well as in biofluids such as urine and saliva. Metabolites as similar as Δ- and Δ-THC, differing only in the position of a double bond, can be distinguished.
一种水溶性主体分子可以在水溶液中结合四氢大麻酚（Δ-THC）及其代谢物。通过将这种识别事件与荧光报告器配对在传感阵列中，并改变外部介体，基于模式识别的检测成为可能，这允许对 THC 代谢物进行选择性区分。这种选择性传感可以在水溶液中以微摩尔灵敏度进行，也可以在尿液和唾液等生物流体中进行。可以区分类似于 Δ-和 Δ-THC 的代谢物，它们仅在双键位置上有所不同。
