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Treatment response to idelalisib in a patient with immunodeficiency-associated Burkitt lymphoma harboring a PIK3CA H1047R mutation.

作者信息

Bleckmann Annalen, Dierks Sascha, Schildhaus Hans-Ulrich, Hellige Niels, Bacher Ulrike, Trümper Lorenz, Wulf Gerald

机构信息

Department of Haematology and Medical Oncology, University Medicine Göttingen, Göttingen, Germany.

Department of Medicine A, Hematology, Oncology and Pneumology, University Hospital Münster, Münster, Germany.

出版信息

Ann Hematol. 2021 Jan;100(1):277-279. doi: 10.1007/s00277-020-03974-y. Epub 2020 Mar 20.

Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3063/7782442/f9450d1b27a5/277_2020_3974_Fig1_HTML.jpg

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本文引用的文献

1
Update on Burkitt Lymphoma.
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The H1047R point mutation in p110 alpha changes the morphology of human colon HCT116 cancer cells.
Cell Death Discov. 2015 Oct 19;1:15044. doi: 10.1038/cddiscovery.2015.44. eCollection 2015.
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Idelalisib for the treatment of non-Hodgkin lymphoma.
Expert Opin Pharmacother. 2016;17(2):265-74. doi: 10.1517/14656566.2016.1135130. Epub 2016 Jan 28.
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Oncogenic mechanisms in Burkitt lymphoma.
Cold Spring Harb Perspect Med. 2014 Feb 1;4(2):a014282. doi: 10.1101/cshperspect.a014282.
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Developments in Burkitt's lymphoma: novel cooperations in oncogenic MYC signaling.
Cancer Manag Res. 2014 Jan 9;6:27-38. doi: 10.2147/CMAR.S37745.
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PIK3CA mutations in advanced cancers: characteristics and outcomes.
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The genetic landscape of mutations in Burkitt lymphoma.
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PIK3CA mutation H1047R is associated with response to PI3K/AKT/mTOR signaling pathway inhibitors in early-phase clinical trials.
Cancer Res. 2013 Jan 1;73(1):276-84. doi: 10.1158/0008-5472.CAN-12-1726. Epub 2012 Oct 12.

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