Frush Harriet L, Isbell Horace S, Fatiadi Alexander J
J Res Natl Bur Stand A Phys Chem. 1960 Sep-Oct;64A(5):433-442. doi: 10.6028/jres.064A.044. Epub 1960 Oct 1.
By reduction of aldoses and aldonic lactones with lithium borohydride-, the following 1-tritium-labeled alditols were prepared: d-arabinitol-, d-lyxitol-, d-ribitol-, d-xylitol-, d-galaetitol-, d-mannitol- ()-, d-glucitol-, d-talitol-, l-gulitol- (d-glucitol ), l-rhamnitol-, d--d--heptitol-, and 4--d-galactopyranosyl-d-glucitol-. By reduction of ketoses with lithium borohydride-, the following epimeric pairs of 2-labeled alditols were prepared and subsequently separated: d-mannitol-()- and d-glucitol-; l-gulitol- (d-glucitol-5-) and l-iditol-; d-galactitol-2- and d-talitol-; d--d--heptitol- and d--d--heptitol-; and d--heptitol- and d--d--heptitol-. The yields of the epimeric alditols formed from ketoses were determined by an isotopedilution technique. Stereomeric relationships are discussed for the labeled alditols and for the ketoses derivable from them by oxidation with .
通过用硼氢化锂还原醛糖和醛糖酸内酯，制备了以下1-氚标记的糖醇：d-阿拉伯糖醇、d-来苏糖醇、d-核糖醇、d-木糖醇、d-半乳糖醇、d-甘露糖醇（）、d-葡萄糖醇、d-塔罗糖醇、l-古洛糖醇（d-葡萄糖醇）、l-鼠李糖醇、d--d--庚糖醇和4--d-吡喃半乳糖基-d-葡萄糖醇。通过用硼氢化锂还原酮糖，制备了以下2-标记的糖醇差向异构体对，随后进行了分离：d-甘露糖醇（）-和d-葡萄糖醇；l-古洛糖醇（d-葡萄糖醇-5-）和l-艾杜糖醇；d-半乳糖醇-2-和d-塔罗糖醇；d--d--庚糖醇和d--d--庚糖醇；以及d--庚糖醇和d--d--庚糖醇。由酮糖形成的差向异构糖醇的产率通过同位素稀释技术测定。讨论了标记糖醇以及通过用氧化可从它们衍生的酮糖的立体异构关系。
