Department of Neurology, Medical University of Bialystok, Bialystok, Poland.
Department of Neurology, Medical University of Bialystok, Bialystok, Poland.
Mult Scler Relat Disord. 2020 Jun;41:102051. doi: 10.1016/j.msard.2020.102051. Epub 2020 Mar 14.
To determine and compare comorbidity levels in the multiple sclerosis (MS) population in Poland using a matched cohort from the general population.
We compared our database (standardized medical histories and medical records) from a MS center at the Department of Neurology, Medical University of Bialystok, Poland) with local National Health Fund (NHF) data (all patients presenting to healthcare facilities with a diagnosis of MS (ICD 10: G35)). We identified 1299 MS cases from the NHF data and 952,434 age and geographically matched controls. We estimated the prevalence of depression, sleep disorders, epilepsy, hypertension, hyperlipidemia, diabetes, atherosclerosis, lung infections, thyroid disease, discopathy, and urinary tract infections in the MS population versus matched controls.
In all, 815 cases of MS (67.6% women and 32.4% men) were registered with the MS center. According to the patients' medical records (with ICD 10 coding), the most common comorbidities were hypertension (4.3%) and thyroid diseases (3.3%). In addition, in standardized medical histories comorbidities were reported by MS patients: depression/depressed mood in 37.6% of patients (67% of whom had sought treatment), pain in 69.6% patients, urinary incontinence in 39.2% patients (44.9% of whom were treated), memory-related problems and fatigue in 39.2% and 70.8% patients, respectively. In the local NHF data, the most common comorbidities were hypertension (8%), diseases that cause back pain [ICD 10:M50-54 (4.3%),G54-55 (3%), M47-48 (5.4%)], urinary tract infection (3.5%), depression (2.4%), hyperlipidemia (2%), and diabetes (2%). All comorbidities except depression and sleep disorders were more common in the matched controls than in the MS population. Diabetes and hyperlipidemia in the MS population were more common in men than women. Most patients (89%) were not treated with disease-modifying therapies.
The most common comorbidity in the MS population is hypertension. The MS population has an increased prevalence of depression versus the matched controls. MS patients-especially men and older individuals-are at increased risk of developing vascular diseases.
本研究旨在通过与波兰一般人群的匹配队列比较，确定并评估多发性硬化症（MS）患者的合并症水平。
我们比较了波兰比亚韦斯托克医科大学神经科 MS 中心的数据库（标准化病史和病历）与当地国家卫生基金（NHF）数据（所有在医疗机构就诊并被诊断为 MS 的患者（ICD 10：G35））。我们从 NHF 数据中确定了 1299 例 MS 病例和 952434 例年龄和地理位置相匹配的对照者。我们评估了 MS 患者与匹配对照者中抑郁、睡眠障碍、癫痫、高血压、高血脂、糖尿病、动脉粥样硬化、肺部感染、甲状腺疾病、椎间盘疾病、尿路感染的患病率。
在 MS 中心共登记了 815 例 MS（87.6%为女性，32.4%为男性）病例。根据患者病历（ICD 10 编码），最常见的合并症是高血压（4.3%）和甲状腺疾病（3.3%）。此外，在标准化病史中，MS 患者还报告了以下合并症：抑郁/情绪低落占 37.6%（其中 67%的患者寻求了治疗），疼痛占 69.6%，尿失禁占 39.2%（其中 44.9%的患者接受了治疗），记忆力相关问题和疲劳分别占 39.2%和 70.8%。在当地 NHF 数据中，最常见的合并症是高血压（8%）、引起背痛的疾病[ICD 10：M50-54（4.3%）、G54-55（3%）、M47-48（5.4%）]、尿路感染（3.5%）、抑郁（2.4%）、高血脂（2%）和糖尿病（2%）。除了抑郁和睡眠障碍，所有的合并症在匹配对照组中都比 MS 患者中更为常见。MS 患者中，男性的糖尿病和高血脂患病率高于女性。大多数患者（89%）未接受疾病修正治疗。
MS 患者最常见的合并症是高血压。MS 患者的抑郁患病率高于匹配对照组。MS 患者，尤其是男性和年龄较大的患者，发生血管疾病的风险增加。
